PDX Model DetailsTM01212

Request more information on this PDX model.

Model Details

Model ID (Previous ID)
TM01212 (TM01212F)
Primary Site
Pancreas
Tumor Site
Pancreas
Tumor Type
Not Specified
Initial Diagnosis
pancreas adenocarcinoma
Final Diagnosis
pancreas adenocarcinoma
Stage/Grade
Not Specified /

Patient

Sex
Male
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve
Unknown

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 4.04
Sample from passage P1 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:TM01212F463P0     Score:MSI-S
Sample:TM01212F463P0307P1     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
Pancreatic adenocarcinoma with fidelity to P1.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F463 for PDX model TM01212 stained for H&E.

P1 tumor F463 ID306 for PDX model TM01212 stained for H&E.

P1 tumor F463 ID306 for PDX model TM01212 stained for AE1AE3. Staining was positive.

P1 tumor F463 ID306 for PDX model TM01212 stained for CD45. Staining was negative.

P2 tumor F463 ID012 for PDX model TM01212 stained for H&E.

P2 tumor F463 ID012 for PDX model TM01212 stained for AE1AE3. Staining was positive.

P2 tumor F463 ID012 for PDX model TM01212 stained for Ki67. Staining was positive.

P2 tumor F463 ID012 for PDX model TM01212 stained for CD45. Staining was negative.

Dosing Studies