PDX Model DetailsTM01212

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01212 (TM01212F)
Initial Diagnosis
pancreas adenocarcinoma
Final Diagnosis
pancreas adenocarcinoma
Stage/Grade
Not Specified /
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Not Specified

Patient

Sex
Male
Age (at time of tissue collection)
no data
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Samples
Sample from passage P0 has a TMB score of 4.04
Sample from passage P1 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Samples
Sample:TM01212F463P0     Score:MSI-S
Sample:TM01212F463P0307P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1 pathology consistent with pancreatic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F463 for PDX model TM01212 stained for H&E.

P1 tumor F463 ID306 for PDX model TM01212 stained for H&E.

P1 tumor F463 ID306 for PDX model TM01212 stained for AE1AE3. Staining was positive.

P1 tumor F463 ID306 for PDX model TM01212 stained for CD45. Staining was negative.

P2 tumor F463 ID012 for PDX model TM01212 stained for H&E.

P2 tumor F463 ID012 for PDX model TM01212 stained for AE1AE3. Staining was positive.

P2 tumor F463 ID012 for PDX model TM01212 stained for Ki67. Staining was positive.

P2 tumor F463 ID012 for PDX model TM01212 stained for CD45. Staining was negative.

Dosing Studies

no data

Circos Plots

no data