PDX Model DetailsTM01245

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01245 (TM01245F)
Initial Diagnosis
Lung squamous cell carcinoma
Final Diagnosis
Lung squamous cell carcinoma
Stage/Grade
AJCC IB / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
56
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01245F588P0 from passage P0 has a TMB score of 12.92
Sample TM01245F589P0 from passage P0 has a TMB score of 12.92
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01245F588P0 from passage P0     Score:MSI-S
Sample:TM01245F589P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1,P2 pathology consistent with lung squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F588 ID096 for PDX model TM01245 stained for H&E.
P1 tumor F588 ID096 for PDX model TM01245 stained for AE1AE3. Staining was positive.

P1 tumor F588 ID096 for PDX model TM01245 stained for CD45. Staining was negative.
P1 tumor F588 ID096 for PDX model TM01245 stained for KI67. Staining was positive.

P2 tumor F588 ID015 for PDX model TM01245 stained for H&E.
P2 tumor F588 ID015 for PDX model TM01245 stained for AE1AE3. Staining was positive.

P2 tumor F588 ID015 for PDX model TM01245 stained for CD45. Staining was negative.
P2 tumor F588 ID015 for PDX model TM01245 stained for Ki67. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data