PDX Model DetailsTM01273

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01273 (TM01273F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IIA / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
65
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01273F707P0 from passage P0 has a TMB score of 7.27
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01273F707P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with invasive ductal carcinoma. P1 pathology consistent with breast carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM01273.
P0 tumor #707 for PDX model TM01273. Sheets of pleomorphic cells.

P1 tumor F707 ID001 for PDX model TM01273 stained for AR. Staining was negative.
P1 tumor F707 ID001 for PDX model TM01273 stained for ER. Staining was negative.

P1 tumor F707 ID001 for PDX model TM01273 stained for ERBB2 (HER2). Staining was negative.
P1 tumor F707 ID001 for PDX model TM01273 stained for PR. Staining was negative.

Dosing Studies

Circos Plots

 no data