PDX Model DetailsTM01302

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01302 (TM01302F)
Initial Diagnosis
Sarcoma
Final Diagnosis
Leiomyosarcoma
Stage/Grade
Not Specified / Grade:high
Primary Site
Bone
Sample Site
Bone
Tumor Type
Primary Malignancy

Patient
Sex
Male
Age (at time of tissue collection)
46
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01302F816P0 from passage P0 has a TMB score of 0.81
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01302F816P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with sarcoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F815 for PDX model TM01302 stained for H&E.
P0 tumor F815 for PDX model TM01302 stained for AE1/AE3. Staining was negative.

P0 tumor F815 for PDX model TM01302 stained for CD45. Staining was negative.

Dosing Studies

 no data

Circos Plots

 no data