PDX Model DetailsTM01340

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01340 (TM01340F)
Initial Diagnosis
Colon carcinoma
Final Diagnosis
Colon carcinoma
Stage/Grade
Not Specified /
Primary Site
Colon
Sample Site
Colon
Tumor Type
Not Specified

Patient

Sex
Female
Age (at time of tissue collection)
78
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample TM01340F884P0 from passage P0 has a TMB score of 4.85
Sample TM01340F885P0 from passage P0 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:TM01340F884P0 from passage P0     Score:MSI-S
Sample:TM01340F885P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F884 for PDX model TM01340 stained for H&E.

P0 tumor F884 for PDX model TM01340 stained for AE1AE3. Staining was positive.

P0 tumor F884 for PDX model TM01340 stained for CD45. Staining was negative.

P0 tumor F884 for PDX model TM01340 stained for Ki67. Staining was positive.

P1 tumor F884 ID010 for PDX model TM01340 stained for H&E.

P1 tumor F884 ID010 for PDX model TM01340 stained for AE1AE3. Staining was positive.

P1 tumor F884 ID010 for PDX model TM01340 stained for CD45. Staining was negative.

P1 tumor F884 ID010 for PDX model TM01340 stained for Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots

no data