PDX Model DetailsTM01357

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01357 (TM01357F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Lung
Sample Site
Brain
Tumor Type
Metastatic

Related Models

 PDX models TM00233 and TM01357 originated from the same patient.

Patient
Sex
Female
Age (at time of tissue collection)
48
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Yes / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01357F942P0 from passage P0 has a TMB score of 11.31
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01357F942P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 pathology consistent with carcinoma, favor Adenocarcinoma. P1 pathology consistent with poorly differentiated adenocarcinoma of lung.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Primary tumor for PDX model TM01357 stained for H&E. This is a 4x image.
Primary tumor for PDX model TM01357 stained for H&E. This is a 20x image.

P1 tumor F942 P1 ID038 for PDX model TM01357 stained for H&E.
P1 tumor F942 P1 ID038 for PDX model TM01357 stained for AE1AE3. Staining was positive.

P1 tumor F942 P1 ID038 for PDX model TM01357 stained for CD45. Staining was negative.
P1 tumor F942 P1 ID038 for PDX model TM01357 stained for KI67. Staining was positive.

P2 tumor F942 P2 ID013 for PDX model TM01357 stained for H&E. This is a 4x image.
P2 tumor F942 P2 ID013 for PDX model TM01357 stained for H&E. This is a 20x image.

Dosing Studies

 no data

Circos Plots

 no data