PDX Model DetailsTM01386

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01386 (TM01386F)
Initial Diagnosis
Melanoma
Final Diagnosis
Melanoma
Stage/Grade
Not Specified /
Primary Site
Skin
Sample Site
Chest wall
Tumor Type
Primary Malignancy

Patient

Sex
Male
Age (at time of tissue collection)
60
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample TM01386F1075P0 from passage P0 has a TMB score of 21.81
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:TM01386F1075P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P1 pathology consistent with melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F1075 for PDX model TM01386 stained with H&E.

P1 tumor F1075 ID066 for PDX model TM01386 stained with H&E.

P1 tumor F1075 ID070 for PDX model TM01386 stained with H&E.

P1 tumor F1075 ID068 for PDX model TM01386 stained with AE1AE3. Staining was negative.

P1 tumor F1075 ID068 for PDX model TM01386 stained with CD45. Staining was negative.

P1 tumor F1075 ID068 for PDX model TM01386 stained with S100. Staining was positive.

P1 tumor F1075 ID066 for PDX model TM01386 stained for Ki67. Staining was positive.

P2 tumor F1075 ID011 for PDX model TM01386 stained for Ae1AE3. Staining was negative.

Dosing Studies

Circos Plots

no data