PDX Model DetailsTM01423

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Model Details

Model ID (Previous ID)
TM01423
Previous ID
KD1349F
Primary Site
Kidney
Tumor Site
Bone
Tumor Type
Metastatic
Initial Diagnosis
renal cell carcinoma
Final Diagnosis
renal cell carcinoma
Stage/Grade
AJCC IV /

Patient

Sex
Female
Age
80
Race/Ethnicity
White / Not Reported
Treatment Naïve
Yes

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Fine needle aspirate

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 5.66
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:KD1349F117P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P2 pathology consistent with squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P2 tumor F118 ID020 for PDX model TM01423 stained for H&E.

P2 tumor F118 ID020 for PDX model TM01423 stained for AE1AE3. Staining was positive.

P2 tumor F118 ID020 for PDX model TM01423 stained for CD45. Staining was negative

P2 tumor F118 ID020 for PDX model TM01423 stained for Ki67. Staining was positive.

Dosing Studies