PDX Model DetailsTM01441

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01441 (TM01441F)
Initial Diagnosis
Melanoma
Final Diagnosis
Melanoma
Stage/Grade
III /
Primary Site
Skin
Sample Site
Skin
Tumor Type
Metastatic

Patient

Sex
Male
Age (at time of tissue collection)
47
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample TM01441F1236P0 from passage P0 has a TMB score of 6.46
Sample TM01441F1237P0 from passage P0 has a TMB score of 7.27
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:TM01441F1236P0 from passage P0     Score:MSI-S
Sample:TM01441F1237P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1 pathology consistent with Melanoma including pigment.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F1236 for PDX model TM01441 stained for H&E.

P1 tumor F1236 ID071 for PDX model TM01441 stained for H&E.

Dosing Studies

no data

Circos Plots

no data