PDX Model DetailsTM01509

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01509 (TM01509F)
Initial Diagnosis
Melanoma
Final Diagnosis
Melanoma
Stage/Grade
AJCC IV /
Primary Site
Skin
Sample Site
Lung
Tumor Type
Metastatic

Patient

Sex
Male
Age (at time of tissue collection)
66
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample TM01509F041P0 from passage P0 has a TMB score of 73.48
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:TM01509F041P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 and P1 are consistent with melanoma. P2 is consistent with metastatic melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F041 for PDX model TM01509 stained with H&E.

P1 tumor F041 ID229 for PDX model TM01509 stained with H&E.

P1 tumor F041 ID229 for PDX model TM01509 stained with CD45. Staining was negative.

P2 tumor F041 ID009 for PDX model TM01509 stained with H&E.

P2 tumor F041 ID009 for PDX model TM01509 stained with AE1AE3. Staining was negative.

P2 tumor F041 ID009 for PDX model TM01509 stained with CD45. Staining was negative.

P2 tumor F041 ID009 for PDX model TM01509 stained with Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots

no data