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Last Database Update
2019-07-14
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM01509 Previous ID:TM01509F
Primary Site:Skin Initial Diagnosis:melanoma Final Diagnosis:melanoma
Tumor Site:Lung Tumor Type:Metastatic Stage / Grade:AJCC IV /
Patient
Sex:Male Age:66 Race / Ethnicity:Not Reported / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site:Right Flank Sample Type:Not Specified
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 76.71
TMB Range:0.81-289.88  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P0 and P1 are consistent with melanoma. P2 is consistent with metastatic melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F041 for PDX model TM01509 stained with H&E.

P1 tumor F041 ID229 for PDX model TM01509 stained with H&E.

P1 tumor F041 ID229 for PDX model TM01509 stained with CD45. Staining was negative.

P2 tumor F041 ID009 for PDX model TM01509 stained with H&E.

P2 tumor F041 ID009 for PDX model TM01509 stained with AE1AE3. Staining was negative.

P2 tumor F041 ID009 for PDX model TM01509 stained with CD45. Staining was negative.

P2 tumor F041 ID009 for PDX model TM01509 stained with Ki67. Staining was positive.