PDX Model DetailsTM01594

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01594 (TM01594F)
Initial Diagnosis
Glioblastoma
Final Diagnosis
Glioblastoma
Stage/Grade
Not Specified / Grade:4
Primary Site
Brain
Sample Site
Brain
Tumor Type
Primary Malignancy

Patient
Sex
Male
Age (at time of tissue collection)
13
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample TM01594F062P2 from passage P2 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01594F062P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
The morphology is completely consistent patient to P2 in all models. P2 pathology consistent with Glial tumor.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM01594.
P0 tumor for PDX model TM01594.

P2 tumor for PDX model TM01594 stained with H&E.
P2 tumor F006 ID11 for PDX model TM01594 stained with H&E.

P2 tumor F006 ID11 for PDX model TM01594 stained with AE1AE3. Staining was positive.
P2 tumor F006 ID11 for PDX model TM01594 stained with CD45. Staining was negative.

P2 tumor F006 ID11 for PDX model TM01594 stained with Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data