PDX Model DetailsTM01611

Request information on the availability of this model.

PDX Model Summary

Model Details
Model ID (Previous ID)
TM01611 (TM01611F)
Initial Diagnosis
Colon adenocarcinoma
Final Diagnosis
Colon adenocarcinoma
Stage/Grade
Not Specified /
Primary Site
Colon
Sample Site
Liver
Tumor Type
Metastatic

Patient
Sex
Male
Age (at time of tissue collection)
58
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01611F457P0 from passage P0 has a TMB score of 0.0
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01611F457P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F457 ID007 for PDX model TM01611 stained for H&E.
P1 tumor F457 ID007 for PDX model TM01611 stained for AE1AE3. Staining was positive.

P1 tumor F457 ID007 for PDX model TM01611 stained for CD45. Staining was negative.
P1 tumor F457 ID007 for PDX model TM01611 stained for Ki67. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data