PDX Model DetailsTM01611

Request more information on this PDX model.

Model Details

Model ID (Previous ID)
TM01611 (TM01611F)
Primary Site
Colon
Tumor Site
Liver
Tumor Type
Metastatic
Initial Diagnosis
colon adenocarcinoma
Final Diagnosis
colon adenocarcinoma
Stage/Grade
Not Specified /

Patient

Sex
Male
Age
58
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve
Unknown

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site
Right Flank
Sample Type
Not Specified

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 0.0
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:TM01611F457P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P1 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F457 ID007 for PDX model TM01611 stained for H&E.

P1 tumor F457 ID007 for PDX model TM01611 stained for AE1AE3. Staining was positive.

P1 tumor F457 ID007 for PDX model TM01611 stained for CD45. Staining was negative.

P1 tumor F457 ID007 for PDX model TM01611 stained for Ki67. Staining was positive.

Dosing Studies