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Last Database Update
2020-07-05
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM01612 Previous ID:TM01612F
Primary Site:Skin Initial Diagnosis:melanoma Final Diagnosis:melanoma
Tumor Site:Lymph node Tumor Type:Metastatic Stage / Grade:AJCC IV /
Patient
Sex:Male Age:50 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site:Right Flank Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 1.62
Sample from passage P1 has a TMB score of 1.62
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:TM01612F464P0001P1     Score:MSI-S
Sample:TM01612F464P0     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
TM-01612 consistent with melanoma and has fidelity to P1.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F464 for PDX model TM01612 stained with H&E.

P1 tumor F464 ID001 for PDX model TM01612 stained with H&E.