PDX Model DetailsTM01612

PDX Model Summary
Model Details	Model ID (Previous ID) TM01612 (TM01612F) Initial Diagnosis Melanoma Final Diagnosis Melanoma Stage/Grade AJCC IV / Primary Site Skin Sample Site Lymph node Tumor Type Metastatic
Publications citing this model	Ishak Gabra MB; et al. Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth. Nat Commun. 2020 Jul 3;11(1):3326. doi: 10.1038/s41467-020-17181-w
Patient	Sex Male Age (at time of tissue collection) 50 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? No Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample TM01612F464P0 from passage P0 has a TMB score of 0.81 Sample TM01612F464P0001P1 from passage P1 has a TMB score of 1.62 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:TM01612F464P0 from passage P0 Score:MSI-S Sample:TM01612F464P0001P1 from passage P1 Score:MSI-S
Gene Fusion	no data

Model Characterization

Summary:
P1 pathology consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F464 for PDX model TM01612 stained with H&E.

P1 tumor F464 ID001 for PDX model TM01612 stained with H&E.

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