PDX Model DetailsTM01612

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01612 (TM01612F)
Initial Diagnosis
melanoma
Final Diagnosis
melanoma
Stage/Grade
AJCC IV /
Primary Site
Skin
Sample Site
Lymph node
Tumor Type
Metastatic

Patient

Sex
Male
Age (at time of tissue collection)
50
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Samples
Sample from passage P0 has a TMB score of 0.81
Sample from passage P1 has a TMB score of 1.62
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Samples
Sample:TM01612F464P0001P1     Score:MSI-S
Sample:TM01612F464P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P1 pathology consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F464 for PDX model TM01612 stained with H&E.

P1 tumor F464 ID001 for PDX model TM01612 stained with H&E.

Dosing Studies

no data

Circos Plots

no data