Mouse Tumor Biology Database (MTB)
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Last Database Update
2018-04-15
MTB 3.0
 
Help Patient Derived Xenograft Search Form
 Patient Derived Xenograft (PDX) models for cancer research are created by the implantation of human cells and tumor tissue into immune compromised mouse hosts. PDX models provide a platform for in vivo cancer biology studies and pre-clinical cancer drug efficacy testing. The current state of the art mouse host is the "NOD-SCID-Gamma2" (NSG) mouse. NSG mice lack mature T and B cells, have no functional natural killer cells, and are deficient in both innate immunity and cytokine signaling.
 


PDX minimal information data standards are now public. Read about it in Cancer Research, Meehan et al., 2017


 NSG Mouse
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