Reference SummaryDasenbrock C, Exp Toxicol Pathol 2005 Apr;56(6):351-60

Title

Maternal effects and cancer risk in the progeny of mice exposed to X-rays before conception.

Authors

Dasenbrock C; Tillmann T; Ernst H; Behnke W; Kellner R; Hagemann G; Kaever V; Kohler M; Rittinghausen S; Mohr U; Tomatis L

Journal

Exp Toxicol Pathol

Volume

56

Issue

6

Year

2005

Pages

351-60

Abstract

To investigate in an animal model whether preconceptual X-ray exposure leads to an altered tumor rate and spectrum in the offspring, a transgeneration carcinogenesis study was carried out. Female mice received X-ray irradiation (2 x 2 Gray) 2 weeks prior to mating with untreated males. After weaning, half of the descendants were exposed for 6 months to the immunomodulating and tumor-promoting compound cyclosporine A (CsA) by diet, the others remained untreated. The animals were maintained for their entire lifespan, terminal sacrifices were carried out after 28 months. Complete autopsy was performed, and three protocol organs (lung, liver and spleen) were examined histologically, together with any suspicious lesions in other organs. Fertility and the lifetime of the maternal mice were reduced by the X-ray irradiation, and their incidence of lung and liver tumors was increased as compared to non-irradiated mice. The descendants of all groups revealed comparable body weights and mortality rates. The incidence of hematopoietic/lymphoreticular tissue tumors increased in the female hybrids by 6 months of CsA-treatment. A higher incidence of lung and liver tumors in the sham-treated male progeny of irradiated mothers was detected, pointing to a possible germ cell-transmitted alteration initiated by the preconceptual maternal X-ray exposure.

Links

15945274 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6N Blood vessel hemangioma Liver

1.4

C57BL/6N Blood vessel hemangioma
  • X-radiation
Liver

0.4

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Liver

0 - 1.9

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma
  • Cyclosporin A
Liver

0 - 0.5

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma
  • X-radiation
Liver

0.5 - 1.0

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma
  • X-radiation
  • Cyclosporin A
Liver

0.5 - 1.0

C57BL/6N Blood vessel hemangiosarcoma Liver

1.4

C57BL/6N Blood vessel hemangiosarcoma
  • X-radiation
Liver

0.4

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Liver

2.3 - 7.0

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma
  • Cyclosporin A
Liver

0.5 - 4.7

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma
  • X-radiation
Liver

1.0 - 6.2

(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma
  • X-radiation
  • Cyclosporin A
Liver

1.9 - 4.3

C57BL/6N Blood vessel tumor Liver

2.7

C57BL/6N Blood vessel tumor
  • X-radiation
Liver

0.9

(C57BL/6N x C3H/HeN)F1 Blood vessel tumor Liver

3.8 - 7.0

(C57BL/6N x C3H/HeN)F1 Blood vessel tumor
  • Cyclosporin A
Liver

0.5 - 5.2

(C57BL/6N x C3H/HeN)F1 Blood vessel tumor
  • X-radiation
Liver

1.9 - 6.7

(C57BL/6N x C3H/HeN)F1 Blood vessel tumor
  • X-radiation
  • Cyclosporin A
Liver

2.4 - 5.2

C57BL/6N Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

11.4

C57BL/6N Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • X-radiation
Leukocyte - Monocyte - Macrophage - Histiocyte

8.3

(C57BL/6N x C3H/HeN)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

3.8 - 4.7

(C57BL/6N x C3H/HeN)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • Cyclosporin A
Leukocyte - Monocyte - Macrophage - Histiocyte

3.8 - 6.1

(C57BL/6N x C3H/HeN)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • X-radiation
Leukocyte - Monocyte - Macrophage - Histiocyte

1.9 - 4.9

(C57BL/6N x C3H/HeN)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • X-radiation
  • Cyclosporin A
Leukocyte - Monocyte - Macrophage - Histiocyte

2.4 - 4.8

C57BL/6N Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1.4

C57BL/6N Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • X-radiation
Leukocyte - Myelocyte (Granulocyte)

1.3

(C57BL/6N x C3H/HeN)F1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

(C57BL/6N x C3H/HeN)F1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • Cyclosporin A
Leukocyte - Myelocyte (Granulocyte)

0

(C57BL/6N x C3H/HeN)F1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • X-radiation
Leukocyte - Myelocyte (Granulocyte)

0

(C57BL/6N x C3H/HeN)F1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • X-radiation
  • Cyclosporin A
Leukocyte - Myelocyte (Granulocyte)

0.5

C57BL/6N Leukocyte lymphoma Leukocyte

50.7

C57BL/6N Leukocyte lymphoma
  • X-radiation
Leukocyte

59.1

(C57BL/6N x C3H/HeN)F1 Leukocyte lymphoma Leukocyte

13.1 - 39.9

(C57BL/6N x C3H/HeN)F1 Leukocyte lymphoma
  • Cyclosporin A
Leukocyte

19.8 - 52.4

(C57BL/6N x C3H/HeN)F1 Leukocyte lymphoma
  • X-radiation
Leukocyte

18.1 - 42.2

(C57BL/6N x C3H/HeN)F1 Leukocyte lymphoma
  • X-radiation
  • Cyclosporin A
Leukocyte

15.7 - 56.5

(C57BL/6N x C3H/HeN)F1 Liver - Sinusoid - Ito cell tumor Liver - Sinusoid - Ito cell

0.9 - 1.4

(C57BL/6N x C3H/HeN)F1 Liver - Sinusoid - Ito cell tumor
  • Cyclosporin A
Liver - Sinusoid - Ito cell

0

(C57BL/6N x C3H/HeN)F1 Liver - Sinusoid - Ito cell tumor
  • X-radiation
Liver - Sinusoid - Ito cell

0 - 1.9

(C57BL/6N x C3H/HeN)F1 Liver - Sinusoid - Ito cell tumor
  • X-radiation
  • Cyclosporin A
Liver - Sinusoid - Ito cell

0

(C57BL/6N x C3H/HeN)F1 Liver hepatoblastoma Liver

0

(C57BL/6N x C3H/HeN)F1 Liver hepatoblastoma
  • Cyclosporin A
Liver

0

(C57BL/6N x C3H/HeN)F1 Liver hepatoblastoma
  • X-radiation
Liver

0.5

(C57BL/6N x C3H/HeN)F1 Liver hepatoblastoma
  • X-radiation
  • Cyclosporin A
Liver

0

C57BL/6N Liver hepatocellular adenoma Liver

2.7

C57BL/6N Liver hepatocellular adenoma
  • X-radiation
Liver

3.9

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular adenoma Liver

6.1 - 14.6

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular adenoma
  • Cyclosporin A
Liver

5.2 - 14.6

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular adenoma
  • X-radiation
Liver

2.4 - 16.7

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular adenoma
  • X-radiation
  • Cyclosporin A
Liver

4.8 - 18.1

C57BL/6N Liver hepatocellular carcinoma Liver

0.5

C57BL/6N Liver hepatocellular carcinoma
  • X-radiation
Liver

3.9

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular carcinoma Liver

4.2 - 16.4

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular carcinoma
  • Cyclosporin A
Liver

1.9 - 21.7

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular carcinoma
  • X-radiation
Liver

6.8 - 25.2

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular carcinoma
  • X-radiation
  • Cyclosporin A
Liver

1.9 - 27.1

C57BL/6N Liver hepatocellular tumor Liver

3.2

C57BL/6N Liver hepatocellular tumor
  • X-radiation
Liver

7.8

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular tumor Liver

10.3 - 29.6

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular tumor
  • Cyclosporin A
Liver

7.1 - 34.0

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular tumor
  • X-radiation
Liver

8.7 - 39.0

(C57BL/6N x C3H/HeN)F1 Liver hepatocellular tumor
  • X-radiation
  • Cyclosporin A
Liver

6.7 - 41.9

C57BL/6N Lung adenoma Lung

2.3

C57BL/6N Lung adenoma
  • X-radiation
Lung

7.0

(C57BL/6N x C3H/HeN)F1 Lung adenoma Lung

6.6 - 12.7

(C57BL/6N x C3H/HeN)F1 Lung adenoma
  • Cyclosporin A
Lung

4.7 - 13.2

(C57BL/6N x C3H/HeN)F1 Lung adenoma
  • X-radiation
Lung

3.9 - 21.0

(C57BL/6N x C3H/HeN)F1 Lung adenoma
  • X-radiation
  • Cyclosporin A
Lung

7.2 - 16.7

C57BL/6N Lung carcinoma Lung

0.9

C57BL/6N Lung carcinoma
  • X-radiation
Lung

3.9

(C57BL/6N x C3H/HeN)F1 Lung carcinoma Lung

7.0 - 14.6

(C57BL/6N x C3H/HeN)F1 Lung carcinoma
  • Cyclosporin A
Lung

2.4 - 16.5

(C57BL/6N x C3H/HeN)F1 Lung carcinoma
  • X-radiation
Lung

7.3 - 21.0

(C57BL/6N x C3H/HeN)F1 Lung carcinoma
  • X-radiation
  • Cyclosporin A
Lung

2.9 - 22.9

(C57BL/6N x C3H/HeN)F1 Lung carcinoma - acinar Lung

0 - 0.5

(C57BL/6N x C3H/HeN)F1 Lung carcinoma - acinar
  • Cyclosporin A
Lung

0

(C57BL/6N x C3H/HeN)F1 Lung carcinoma - acinar
  • X-radiation
Lung

0 - 0.5

(C57BL/6N x C3H/HeN)F1 Lung carcinoma - acinar
  • X-radiation
  • Cyclosporin A
Lung

0 - 0.5

C57BL/6N Lung papilloma Lung

0

C57BL/6N Lung papilloma
  • X-radiation
Lung

0.4

C57BL/6N Lung tumor Lung

3.2

C57BL/6N Lung tumor
  • X-radiation
Lung

10.9

(C57BL/6N x C3H/HeN)F1 Lung tumor Lung

14.1 - 26.8

(C57BL/6N x C3H/HeN)F1 Lung tumor
  • Cyclosporin A
Lung

7.1 - 28.3

(C57BL/6N x C3H/HeN)F1 Lung tumor
  • X-radiation
Lung

10.7 - 39.0

(C57BL/6N x C3H/HeN)F1 Lung tumor
  • X-radiation
  • Cyclosporin A
Lung

10.0 - 37.1

C57BL/6N (Unspecified organ) tumor (Unspecified organ)

63.5

C57BL/6N (Unspecified organ) tumor
  • X-radiation
(Unspecified organ)

68.7

(C57BL/6N x C3H/HeN)F1 (Unspecified organ) tumor (Unspecified organ)

16.9 - 44.6

(C57BL/6N x C3H/HeN)F1 (Unspecified organ) tumor
  • Cyclosporin A
(Unspecified organ)

25.9 - 56.1

(C57BL/6N x C3H/HeN)F1 (Unspecified organ) tumor
  • X-radiation
(Unspecified organ)

20.0 - 47.1

(C57BL/6N x C3H/HeN)F1 (Unspecified organ) tumor
  • X-radiation
  • Cyclosporin A
(Unspecified organ)

20.5 - 59.3