Reference SummaryYou M, Carcinogenesis 1993 Jun;14(6):1247-9
Title |
K-ras mutations in benzotrichloride-induced lung tumors of A/J mice. |
Authors |
You M; Wang Y; Nash B; Stoner GD |
Journal |
Carcinogenesis |
Volume |
14 |
Issue |
6 |
Year |
1993 |
Pages |
1247-9 |
Abstract |
Benzotrichloride (BTC) is used extensively as a chemical intermediate in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. BTC is also a carcinogen in the A/J mouse lung tumor bioassay. Activated K-ras protooncogenes were detected in BTC-induced lung tumors from A/J mice. The polymerase chain reaction was used to amplify specific DNA segments likely to contain activating mutations, and the amplified DNAs were sequenced to identify the mutation. The activating mutation present in the K-ras gene from all BTC-induced lung tumors (24/24) was a GC-->AT transition in codon 12. Thus, BTC may exert its carcinogenic action by activation of the K-ras protooncogene through a genotoxic mechanism. |
Links |
J:13107 – MGI References 8508514 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| A/J | Lung adenoma |
|
Lung |
observed |