Reference SummaryBueno MJ, Cancer Cell 2008 Jun;13(6):496-506
Title |
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. |
Authors |
Bueno MJ; Perez de Castro I; Gomez de Cedron M; Santos J; Calin GA; Cigudosa JC; Croce CM; Fernandez-Piqueras J; Malumbres M |
Journal |
Cancer Cell |
Volume |
13 |
Issue |
6 |
Year |
2008 |
Pages |
496-506 |
Abstract |
The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 Mb region encodes about 12% of all genomic microRNAs, including miR-203. This microRNA is additionally hypermethylated in several hematopoietic tumors, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. A putative miR-203 target, ABL1, is specifically activated in these hematopoietic malignancies in some cases as a BCR-ABL1 fusion protein (Philadelphia chromosome). Re-expression of miR-203 reduces ABL1 and BCR-ABL1 fusion protein levels and inhibits tumor cell proliferation in an ABL1-dependent manner. Thus, miR-203 functions as a tumor suppressor, and re-expression of this microRNA might have therapeutic benefits in specific hematopoietic malignancies. |
Links |
J:138632 – MGI References 18538733 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J | Leukocyte - Lymphocyte - T-lymphocyte lymphoma |
|
Thymus |
observed |
|
| (C57BL/6J x RF/J)F1 | Leukocyte - Lymphocyte - T-lymphocyte lymphoma |
|
Thymus |
observed |
|
| C57BL/6J | Leukocyte - Lymphocyte - T-lymphocyte normal tissue (control) |
|
Thymus |
not applicable |