Reference SummaryMcDonald RB, Exp Gerontol 2008 Dec;43(12):1061-8
Title |
Characterization of survival and phenotype throughout the life span in UCP2/UCP3 genetically altered mice. | ||||||||||
Authors |
McDonald RB; Walker KM; Warman DB; Griffey SM; Warden CH; Ramsey JJ; Horwitz BA | ||||||||||
Journal |
Exp Gerontol | ||||||||||
Volume |
43 | ||||||||||
Issue |
12 | ||||||||||
Year |
2008 | ||||||||||
Pages |
1061-8 | ||||||||||
Abstract |
In the present investigation we describe the life span characteristics and phenotypic traits of ad libitum-fed mice that overexpress UCP2/3 (Positive-TG), their non-overexpressing littermates (Negative-TG), mice that do not expression UCP2 (UCP2KO) or UCP3 (UCP3KO), and wild-type C57BL/6J mice (WT-Control). We also included a group of C57BL/6J mice calorie-restricted to 70% of ad libitum-fed mice in order to test partially the hypothesis that UCPs contribute to the life extension properties of CR. Mean survival was slightly, but significantly, greater in Positive-TG, than that observed in Negative-TG or WT-Control; mean life span did not significantly differ from that of the UCP3KO mice. Maximal life span did not differ among the ad libitum-fed groups. Genotype did not significantly affect body weight, food intake, or the type of pathology at time of death. Calorie restriction increased significantly mean and maximal life span, and the expression of UCP2 and UCP3. The lack of difference in maximal life spans among the Positive-TG, Negative-TG, and UCP3KO suggests that UCP3 does not significantly affect longevity in mice. | ||||||||||
Links |
J:143281 – MGI References 18854208 – National Library of Medicine/PubMed |
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Strain Notes
|
|||||||||||
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Blood vessel hemangiosarcoma | Spleen |
5.9 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Blood vessel hemangiosarcoma | Liver |
5.9 |
||
| B6.Cg | Blood vessel hemangiosarcoma | Spleen |
0 |
||
| B6.Cg | Blood vessel hemangiosarcoma | Liver |
0 |
||
| C57BL/6J | Blood vessel hemangiosarcoma | Spleen |
0 |
||
| C57BL/6J | Blood vessel hemangiosarcoma | Liver |
0 |
||
| B6.129S6-Ucp3tm1Rei | Blood vessel hemangiosarcoma | Spleen |
8.3 |
||
| B6.129S6-Ucp3tm1Rei | Blood vessel hemangiosarcoma | Liver |
0 |
||
| C57BL/6J | Blood vessel hemangiosarcoma |
|
Spleen |
0 |
|
| C57BL/6J | Blood vessel hemangiosarcoma |
|
Liver |
0 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Erythrocyte leukemia - erythroleukemia | Spleen |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Erythrocyte leukemia - erythroleukemia | Liver |
0 |
||
| B6.Cg | Erythrocyte leukemia - erythroleukemia | Spleen |
0 |
||
| B6.Cg | Erythrocyte leukemia - erythroleukemia | Liver |
0 |
||
| C57BL/6J | Erythrocyte leukemia - erythroleukemia | Spleen |
0 |
||
| C57BL/6J | Erythrocyte leukemia - erythroleukemia | Liver |
0 |
||
| B6.129S6-Ucp3tm1Rei | Erythrocyte leukemia - erythroleukemia | Spleen |
0 |
||
| B6.129S6-Ucp3tm1Rei | Erythrocyte leukemia - erythroleukemia | Liver |
0 |
||
| C57BL/6J | Erythrocyte leukemia - erythroleukemia |
|
Spleen |
3.3 |
|
| C57BL/6J | Erythrocyte leukemia - erythroleukemia |
|
Liver |
3.3 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Kidney - Cortex cyst | Kidney - Cortex |
0 |
||
| B6.Cg | Kidney - Cortex cyst | Kidney - Cortex |
13 |
||
| C57BL/6J | Kidney - Cortex cyst | Kidney - Cortex |
7.7 |
||
| B6.129S6-Ucp3tm1Rei | Kidney - Cortex cyst | Kidney - Cortex |
0 |
||
| C57BL/6J | Kidney - Cortex cyst |
|
Kidney - Cortex |
0 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Kidney tumor - round cell | Kidney |
0 |
||
| B6.Cg | Kidney tumor - round cell | Kidney |
0 |
||
| C57BL/6J | Kidney tumor - round cell | Kidney |
0 |
||
| B6.129S6-Ucp3tm1Rei | Kidney tumor - round cell | Kidney |
4.2 |
||
| C57BL/6J | Kidney tumor - round cell |
|
Kidney |
0 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Lymphocyte leukemia - lymphocytic | Lung |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Lymphocyte leukemia - lymphocytic | Spleen |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Lymphocyte leukemia - lymphocytic | Liver |
5.9 |
||
| B6.Cg | Leukocyte - Lymphocyte leukemia - lymphocytic | Lung |
0 |
||
| B6.Cg | Leukocyte - Lymphocyte leukemia - lymphocytic | Spleen |
6.7 |
||
| B6.Cg | Leukocyte - Lymphocyte leukemia - lymphocytic | Liver |
6.7 |
||
| C57BL/6J | Leukocyte - Lymphocyte leukemia - lymphocytic | Lung |
7.7 |
||
| C57BL/6J | Leukocyte - Lymphocyte leukemia - lymphocytic | Spleen |
0 |
||
| C57BL/6J | Leukocyte - Lymphocyte leukemia - lymphocytic | Liver |
7.7 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Lymphocyte leukemia - lymphocytic | Lung |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Lymphocyte leukemia - lymphocytic | Spleen |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Lymphocyte leukemia - lymphocytic | Liver |
0 |
||
| C57BL/6J | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Lung |
0 |
|
| C57BL/6J | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Spleen |
6.7 |
|
| C57BL/6J | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Liver |
0 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lung |
5.9 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Abdominal cavity |
5.9 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Spleen |
5.9 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lymph node |
0 |
||
| B6.Cg | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lung |
6.7 |
||
| B6.Cg | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Abdominal cavity |
0 |
||
| B6.Cg | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Spleen |
6.7 |
||
| B6.Cg | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
6.7 |
||
| B6.Cg | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lymph node |
0 |
||
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lung |
0 |
||
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Abdominal cavity |
7.7 |
||
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Spleen |
15 |
||
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
0 |
||
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lymph node |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lung |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Abdominal cavity |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Spleen |
4.2 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Lymph node |
4.2 |
||
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Lung |
0 |
|
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Abdominal cavity |
0 |
|
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Spleen |
10 |
|
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Liver |
23 |
|
| C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Lymph node |
0 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Kidney |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Lung |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Thymus |
5.9 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Spleen |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Liver |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Pancreas |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Leukocyte lymphoma | Lymph node |
12 |
||
| B6.Cg | Leukocyte lymphoma | Kidney |
6.7 |
||
| B6.Cg | Leukocyte lymphoma | Lung |
13 |
||
| B6.Cg | Leukocyte lymphoma | Thymus |
13 |
||
| B6.Cg | Leukocyte lymphoma | Spleen |
6.7 |
||
| B6.Cg | Leukocyte lymphoma | Liver |
13 |
||
| B6.Cg | Leukocyte lymphoma | Pancreas |
6.7 |
||
| B6.Cg | Leukocyte lymphoma | Lymph node |
6.7 |
||
| C57BL/6J | Leukocyte lymphoma | Kidney |
0 |
||
| C57BL/6J | Leukocyte lymphoma | Lung |
0 |
||
| C57BL/6J | Leukocyte lymphoma | Thymus |
0 |
||
| C57BL/6J | Leukocyte lymphoma | Spleen |
0 |
||
| C57BL/6J | Leukocyte lymphoma | Liver |
7.7 |
||
| C57BL/6J | Leukocyte lymphoma | Pancreas |
0 |
||
| C57BL/6J | Leukocyte lymphoma | Lymph node |
15 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Kidney |
4.2 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Lung |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Thymus |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Spleen |
4.2 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Liver |
4.2 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Pancreas |
0 |
||
| B6.129S6-Ucp3tm1Rei | Leukocyte lymphoma | Lymph node |
4.2 |
||
| C57BL/6J | Leukocyte lymphoma |
|
Kidney |
6.7 |
|
| C57BL/6J | Leukocyte lymphoma |
|
Lung |
0 |
|
| C57BL/6J | Leukocyte lymphoma |
|
Thymus |
3.3 |
|
| C57BL/6J | Leukocyte lymphoma |
|
Spleen |
6.7 |
|
| C57BL/6J | Leukocyte lymphoma |
|
Liver |
10 |
|
| C57BL/6J | Leukocyte lymphoma |
|
Pancreas |
0 |
|
| C57BL/6J | Leukocyte lymphoma |
|
Lymph node |
10 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Mesodermal cell/mesoblast sarcoma - round cell | Lung |
0 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Mesodermal cell/mesoblast sarcoma - round cell | Liver |
5.9 |
||
| B6.Cg-Tg(UCP3,UCP2)1Ful | Mesodermal cell/mesoblast sarcoma - round cell | Lymph node |
0 |
||
| B6.Cg | Mesodermal cell/mesoblast sarcoma - round cell | Lung |
20 |
||
| B6.Cg | Mesodermal cell/mesoblast sarcoma - round cell | Liver |
13 |
||
| B6.Cg | Mesodermal cell/mesoblast sarcoma - round cell | Lymph node |
6.7 |
||
| C57BL/6J | Mesodermal cell/mesoblast sarcoma - round cell | Lung |
0 |
||
| C57BL/6J | Mesodermal cell/mesoblast sarcoma - round cell | Liver |
7.7 |
||
| C57BL/6J | Mesodermal cell/mesoblast sarcoma - round cell | Lymph node |
7.7 |
||
| B6.129S6-Ucp3tm1Rei | Mesodermal cell/mesoblast sarcoma - round cell | Lung |
0 |
||
| B6.129S6-Ucp3tm1Rei | Mesodermal cell/mesoblast sarcoma - round cell | Liver |
12.5 |
||
| B6.129S6-Ucp3tm1Rei | Mesodermal cell/mesoblast sarcoma - round cell | Lymph node |
0 |
||
| C57BL/6J | Mesodermal cell/mesoblast sarcoma - round cell |
|
Lung |
3.3 |
|
| C57BL/6J | Mesodermal cell/mesoblast sarcoma - round cell |
|
Liver |
6.7 |
|
| C57BL/6J | Mesodermal cell/mesoblast sarcoma - round cell |
|
Lymph node |
6.7 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
5.9 |
||
| B6.Cg | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
6.7 |
||
| C57BL/6J | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
31 |
||
| B6.129S6-Ucp3tm1Rei | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
12.5 |
||
| C57BL/6J | Pituitary gland - Pars distalis adenoma |
|
Pituitary gland - Pars distalis |
3.3 |
|
| B6.Cg-Tg(UCP3,UCP2)1Ful | Spleen tumor - round cell | Spleen |
0 |
||
| B6.Cg | Spleen tumor - round cell | Spleen |
6.7 |
||
| C57BL/6J | Spleen tumor - round cell | Spleen |
0 |
||
| B6.129S6-Ucp3tm1Rei | Spleen tumor - round cell | Spleen |
4.2 |
||
| C57BL/6J | Spleen tumor - round cell |
|
Spleen |
0 |