Reference SummaryGordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Title

Strain-dependent differences in susceptibility to lung cancer in inbred mice exposed to mainstream cigarette smoke.

Authors

Gordon T; Bosland M

Journal

Cancer Lett

Volume

275

Issue

2

Year

2009

Pages

213-20

Abstract

It is becoming increasingly clear that genetic susceptibility is an important host factor determining the effects of exposure to a number of airborne particles and gases. Although numerous studies have identified a genetic component for spontaneous pulmonary tumor development and for chemically induced lung cancer (e.g., urethane) in mice, a systematic examination of murine inter-strain differences in response to cigarette smoke inhalation has not been conducted. We addressed this research gap by examining the strain distribution pattern of lung cancer in nine inbred strains of mice exposed to 258 mg/m(3) mainstream cigarette smoke for 5 months followed by 4 months of rest. Lung tumors were enumerated on fixed lungs visualized at low magnification and on serial step sections examined microscopically. With the low magnification examination, we observed statistically significant increases in the number of lung tumors in cigarette smoke-exposed A/J and the genetically-related A/HeJ mice (p<0.05). While fewer tumors were identified by the microscopic enumeration method, it confirmed that significant increases in lung tumors occurred only in A/J and A/HeJ mice exposed to cigarette smoke (p<0.05). Thus, as predicted by epidemiologic studies and animal experiments using chemically induced lung cancer models, these findings suggest that genetic host factors play a significant role in the pulmonary tumorigenic response of mice to mainstream cigarette smoke.

Links

19118942 – National Library of Medicine/PubMed

Strain Notes

Strain Note
129S1/SvImJ These mice were purchased from the Jackson Laboratory.
BALB/c These mice were purchased from the Jackson Laboratory but the substrain was not specified.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AKR Leukocyte leukemia Leukocyte

100

AKR Leukocyte leukemia
  • mainstream cigarette smoke (MCS)
Leukocyte

100

A/J Lung adenoma Lung

observed

A/J Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

observed

A/HeJ Lung adenoma Lung

30

A/HeJ Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

55.56

C3H/HeJ Lung adenoma Lung

0

C3H/HeJ Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

0

DBA Lung adenoma Lung

5.26

DBA Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

0

CAST/EiJ Lung adenoma Lung

0

CAST/EiJ Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

0

C57BL/6 Lung adenoma Lung

0

C57BL/6 Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

10

BALB/c Lung adenoma Lung

10

BALB/c Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

21.05

129S1/SvImJ Lung adenoma Lung

0

129S1/SvImJ Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

5.26

SWR Lung adenoma Lung

observed

SWR Lung adenoma
  • mainstream cigarette smoke (MCS)
Lung

68.42

A/J Lung carcinoma Lung

11.11

A/J Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

5

A/HeJ Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

C3H/HeJ Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

DBA Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

observed

CAST/EiJ Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

C57BL/6 Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

BALB/c Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

129S1/SvImJ Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

SWR Lung carcinoma
  • mainstream cigarette smoke (MCS)
Lung

0

A/HeJ Lung carcinoma Lung

0

C3H/HeJ Lung carcinoma Lung

0

DBA Lung carcinoma Lung

0

CAST/EiJ Lung carcinoma Lung

0

C57BL/6 Lung carcinoma Lung

0

BALB/c Lung carcinoma Lung

0

129S1/SvImJ Lung carcinoma Lung

0

SWR Lung carcinoma Lung

40

A/J Lung hyperplasia Lung

observed

A/HeJ Lung hyperplasia Lung

observed

C3H/HeJ Lung hyperplasia Lung

observed

DBA Lung hyperplasia Lung

observed

CAST/EiJ Lung hyperplasia Lung

0

C57BL/6 Lung hyperplasia Lung

observed

BALB/c Lung hyperplasia Lung

observed

129S1/SvImJ Lung hyperplasia Lung

observed

SWR Lung hyperplasia Lung

observed

A/J Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

A/HeJ Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

C3H/HeJ Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

DBA Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

CAST/EiJ Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

0

C57BL/6 Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

BALB/c Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

129S1/SvImJ Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

SWR Lung hyperplasia
  • mainstream cigarette smoke (MCS)
Lung

observed

A/J Lung papilloma Lung

0

A/HeJ Lung papilloma Lung

observed

C3H/HeJ Lung papilloma Lung

0

DBA Lung papilloma Lung

0

CAST/EiJ Lung papilloma Lung

0

C57BL/6 Lung papilloma Lung

0

BALB/c Lung papilloma Lung

0

129S1/SvImJ Lung papilloma Lung

0

SWR Lung papilloma Lung

0

A/J Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

A/HeJ Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

C3H/HeJ Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

DBA Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

CAST/EiJ Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

C57BL/6 Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

BALB/c Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

129S1/SvImJ Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

0

SWR Lung papilloma
  • mainstream cigarette smoke (MCS)
Lung

5.26

A/J Lung tumor Lung

observed - 33.33

A/HeJ Lung tumor Lung

observed - 30

C3H/HeJ Lung tumor Lung

0 - observed

DBA Lung tumor Lung

observed - 5.26

CAST/EiJ Lung tumor Lung

0 - observed

C57BL/6 Lung tumor Lung

0 - observed

BALB/c Lung tumor Lung

observed - 10

129S1/SvImJ Lung tumor Lung

0 - observed

SWR Lung tumor Lung

observed - 60

A/J Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

observed - 60

A/HeJ Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

observed - 55.56

C3H/HeJ Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

0 - observed

DBA Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

0 - observed

CAST/EiJ Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

0 - observed

C57BL/6 Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

observed - 10

BALB/c Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

observed - 21.05

129S1/SvImJ Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

observed - 5.26

SWR Lung tumor
  • mainstream cigarette smoke (MCS)
Lung

observed - 68.42