Reference SummaryAnderson PD, Cancer Res 2009 Apr 15;69(8):3614-8
Title |
The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. | ||||
Authors |
Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH | ||||
Journal |
Cancer Res | ||||
Volume |
69 | ||||
Issue |
8 | ||||
Year |
2009 | ||||
Pages |
3614-8 | ||||
Abstract |
Testicular germ cell tumors (TGCT) are sex limited, occurring only in males with a Y chromosome. Recently, the gr/gr deletion on the human Y chromosome was associated with increased risk of TGCTs. In addition, the presence of Y chromosome sequences is associated with TGCTs in cases of gonadal dysgenesis. TGCTs in strain 129 males recapitulate many aspects of testicular cancer in human infants and can be used to evaluate the role of the Y chromosome in TGCT risk. We used chromosome substitution strains and a sex-reversing mutant to test the role of the Y chromosome on TGCT susceptibility. Our results show that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis. | ||||
Links |
J:147731 – MGI References 19351821 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| 129S1/SvImJ | Testis - Germ cell tumor | Testis - Germ cell |
4.79 |
||
| 129S1/SvImJ-Chr YC57BL/6J | Testis - Germ cell tumor | Testis - Germ cell |
4.86 |
||
| 129S1/SvImJ-Chr YMOLF/EiJ | Testis - Germ cell tumor | Testis - Germ cell |
2.72 |
||
| C57BL/6J-Chr Y129S1/SvImJ | Testis - Germ cell tumor | Testis - Germ cell |
4.86 |
||
| 129S1;FVB/N-Dnd1Ter/+ OdsTg(Dct-Tyr)1220Ove/+ | Testis - Germ cell tumor | Testis - Germ cell |
0 - 17.81 |
||
| 129S1;FVB/N-OdsTg(Dct-Tyr)1220Ove/+ | Testis - Germ cell tumor | Testis - Germ cell |
0 - 2.36 |