Reference SummaryGarcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42
Title |
Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. |
Authors |
Garcia-Fernandez RA; Garcia-Palencia P; Sanchez MA; Gil-Gomez G; Sanchez B; Rollan E; Martin-Caballero J; Flores JM |
Journal |
Lab Invest |
Volume |
91 |
Issue |
11 |
Year |
2011 |
Pages |
1634-42 |
Abstract |
The cell cycle inhibitors p21(Waf1/Cip1) and p27(Kip1) are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of pituitary adenomas, pheochromocytomas and thyroid adenomas. The combined absence of p21 and p27 proteins delays the incidence of radiation-induced thymic lymphomas with a higher apoptotic rate, measured by active caspase-3 and cleaved PARP-1 immunoexpresion. These results provide experimental evidence for a cooperation of both cyclin-dependent kinase inhibitors in tumorigenesis in mice. |
Links |
J:177185 – MGI References 21876534 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
22.2 |
||
| B6.129S2-Cdkn1atm1Tyj | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0 |
||
| B6.129S4-Cdkn1btm1Mlf | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
16.7 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Blood vessel hemangioma | Blood vessel |
0 |
||
| B6.129S2-Cdkn1atm1Tyj | Blood vessel hemangioma | Blood vessel |
10 |
||
| B6.129S4-Cdkn1btm1Mlf | Blood vessel hemangioma | Blood vessel |
0 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Eye - Harderian gland adenoma | Eye - Harderian gland |
5.6 |
||
| B6.129S4-Cdkn1btm1Mlf | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
5.6 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
5.6 |
||
| B6.129S2-Cdkn1atm1Tyj | Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
5.0 |
||
| B6.129S4-Cdkn1btm1Mlf | Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
0 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Leukocyte - Lymphocyte - T-lymphocyte lymphoma |
|
Thymus |
33 |
|
| B6.129S2-Cdkn1atm1Tyj | Leukocyte - Lymphocyte - T-lymphocyte lymphoma |
|
Thymus |
33 |
|
| B6.129S4-Cdkn1btm1Mlf | Leukocyte - Lymphocyte - T-lymphocyte lymphoma |
|
Thymus |
100 |
|
| C57BL/6J | Leukocyte - Lymphocyte - T-lymphocyte lymphoma |
|
Thymus |
100 |
|
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
11.1 |
||
| B6.129S2-Cdkn1atm1Tyj | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
30 |
||
| B6.129S4-Cdkn1btm1Mlf | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Liver hepatocellular adenoma | Liver |
5.6 |
||
| B6.129S2-Cdkn1atm1Tyj | Lung adenoma | Lung |
5.0 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Mammary gland adenocarcinoma | Mammary gland |
5.6 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Pituitary gland - Pars intermedia adenoma | Pituitary gland - Pars intermedia |
33.3 |
||
| B6.129S2-Cdkn1atm1Tyj | Pituitary gland adenoma | Pituitary gland |
5.0 |
||
| B6.129S4-Cdkn1btm1Mlf | Pituitary gland adenoma | Pituitary gland |
27.8 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | Thyroid gland adenoma | Thyroid gland |
11.1 |
||
| B6.129S2-Cdkn1atm1Tyj | Thyroid gland adenoma | Thyroid gland |
0 |
||
| B6.129S4-Cdkn1btm1Mlf | Thyroid gland adenoma | Thyroid gland |
5.6 |
||
| C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf | (Unspecified organ) tumor | (Unspecified organ) |
72.2 |
||
| B6.129S2-Cdkn1atm1Tyj | (Unspecified organ) tumor | (Unspecified organ) |
55 |
||
| B6.129S4-Cdkn1btm1Mlf | (Unspecified organ) tumor | (Unspecified organ) |
50 - 55.6 |