Reference SummaryMcNeill DA, Drug Chem Toxicol 1990;13(1):71-86
Title |
Tumorigenicity of nickel subsulfide in Strain A/J mice. |
Authors |
McNeill DA; Chrisp CE; Fisher GL |
Journal |
Drug Chem Toxicol |
Volume |
13 |
Issue |
1 |
Year |
1990 |
Pages |
71-86 |
Abstract |
The pulmonary tumor response of Strain A mice has been reported to be a rapid and efficient predictor of carcinogenic potential for a variety of chemicals. The route of exposure has usually been by intraperitoneal injection (i.p.) of solubilized materials. We compared intratracheal (i.t.) instillation as a more representative route typical of human exposures, with i.p. injection of nickel subsulfide, a potent animal carcinogen. Animals were sacrificed either 20 weeks after the first dosing, or were held until 45 weeks after the first dosing. Urethane, a positive control, produced a significant increase in pulmonary tumor response after i.t. instillation as well as i.p. injection. For nickel subsulfide treated animals, there was no evidence of a dose-related increase in pulmonary tumor response in any i.p. or i.t. treatment group when compared with age-matched controls. |
Links |
J:22737 – MGI References 2379474 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| A/J | Lung adenoma | Lung |
10 - 80 |
||
| A/J | Lung adenoma |
|
Lung |
80 - 90 |
|
| A/J | Lung adenoma |
|
Lung |
0 - 63 |