Reference SummaryShimkin MB, J Natl Cancer Inst 1966;36():915-35

Title

 Bioassay of 29 alkylating chemicals by the pulmonary-tumor response in strain A mice

Authors

 Shimkin MB; Weisburger JH; Weisburger EK; Gubareff N; Suntzeff V

Journal

 J Natl Cancer Inst

Volume

 36

Issue

Year

 1966

Pages

 915-35

Abstract

Links

 J:22757 – MGI References

Strain Notes

Strain Note
Swiss "general purpose Swiss mice"

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
A/J Kidney adenoma Kidney

1
A/J Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Lung

1
A/J Leukocyte lymphoma Leukocyte

1
A/J Liver hepatoma Liver

1
A/J Lung tumor Lung

0 - 81
A/J Lung tumor
  • nitrogen mustard (HN2)
 Lung

29 - 95
A/J Lung tumor
  • mannitol mustard
 Lung

41 - 91
A/J Lung tumor
  • cyclophosphamide (Cytoxan)
 Lung

40 - 74
A/J Lung tumor
  • melphalan (L-phenylalanine mustard) (L-sarcolysin)
 Lung

40 - 98
A/J Lung tumor
  • chlorambucil mustard
 Lung

47 - 100
A/J Lung tumor
  • uracil mustard
 Lung

56 - 100
A/J Lung tumor
  • benzalpurine mustard (Elderfield purine mustard)
 Lung

19 - 45
A/J Lung tumor
  • naphthylamine mustard
 Lung

40 - 100
A/J Lung tumor
  • aniline mustard
 Lung

67 - 100
A/J Lung tumor
  • hydroquinone mustard (Weatherbee mustard)
 Lung

44 - 64
A/J Lung tumor
  • benzimidazole mustard
 Lung

26 - 100
A/J Lung tumor
  • chloroquine mustard
 Lung

20 - 80
A/J Lung tumor
  • chloroquine mustard pamoate
 Lung

27 - 48
A/J Lung tumor
  • 5-chloroquine mustard
 Lung

17 - 45
A/J Lung tumor
  • 5-chloroquine mustard pamoate
 Lung

24 - 58
A/J Lung tumor
  • quinacrine ethyl mustard/2
 Lung

20 - 67
A/J Lung tumor
  • quinacrine ethyl mustard
 Lung

24 - 67
A/J Lung tumor
  • quinacrine propyl mustard/2
 Lung

23 - 37
A/J Lung tumor
  • quinacrine propyl mustard
 Lung

15 - 30
A/J Lung tumor
  • quinacrine mustard
 Lung

23 - 46
A/J Lung tumor
  • OPSPA
 Lung

39 - 83
A/J Lung tumor
  • thioTEPA (thio-TEPA) (TESPA)
 Lung

29 - 83
A/J Lung tumor
  • aziridyl benzoquinone
 Lung

36 - 86
A/J Lung tumor
  • mannitol myleran
 Lung

27 - 100
A/J Lung tumor
  • chloroethylmesulfan
 Lung

24 - 59
A/J Lung tumor
  • diepoxybutane (L-butadiene epoxide)
 Lung

21 - 78
A/J Lung tumor
  • diepoxypiperazine
 Lung

27 - 62
A/J Lung tumor
  • epoxypropidine
 Lung

14 - 48
A/J Lung tumor
  • epodyl (diglycidyltriethylene glycol)
 Lung

14 - 71
A Lung tumor
  • urethane (ethyl carbamate)
 Lung

high - very high
A Lung tumor
  • nitrogen mustard (HN2)
 Lung

very high
A Lung tumor
  • 3-methylcholanthrene (MCA) (3-MC)
 Lung

very high
A Lung tumor
  • dibenz[a,h]anthracene (1,2,5,6-dibenzanthracene)
 Lung

very high
A Lung tumor
  • 7H-dibenzo[c,g]carbazole (3,4,5,6-dibenzocarbazole) (DBC)
 Lung

high
A Lung tumor
  • 3,4-benzopyrene (benzo[a]pyrene)
 Lung

high
A Lung tumor
  • dibenz[a,j]aceanthrylene (15,16-benzdehydrocholanthrene)
 Lung

high
A Lung tumor
  • dibenz[a,h]acridine (1,2,5,6-dibenzacridine)
 Lung

high
A Lung tumor
  • 8-methylbenzo[c]phenanthrene (2-methyl-3,4-benzophenanthrene)
 Lung

observed
A Lung tumor
  • 7-methylbenzo[a]pyrene (4'-methyl-3,4-benzopyrene)
 Lung

observed
A Lung tumor
  • 5-methoxy-7-propylbenz[a]-anthracene (3-methoxy-10-propyl-1,2-benzanthracene)
 Lung

observed
A Lung tumor
  • benz[a]anthracene (1,2-benzanthracene)
 Lung

observed
A Lung tumor
  • 4-o-tolylazo-o-toluidine (2-amino-5-azotoluene)
 Lung

high
DD Lung tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Lung

very high
BALB/c Lung tumor
  • hydrazine sulfate
 Lung

high
Swiss Lung tumor
  • N-isopropyl-a-(2-methylhyrazino)-p-toluamide hydrochloride
 Lung

high
A/J Mammary gland adenocarcinoma Mammary gland

1
A/J Ovary - Granulosa cell tumor Ovary - Granulosa cell

1
A/J Salivary gland carcinoma Salivary gland

1
A/J Thymus thymoma Thymus

1
A/J Urinary bladder papilloma
  • uracil mustard
 Urinary bladder

1