Reference SummaryPettan-Brewer C, Pathobiol Aging Age Relat Dis 2011;1():

Title

Practical pathology of aging mice.

Authors

Pettan-Brewer C; Treuting PM

Journal

Pathobiol Aging Age Relat Dis

Volume

1

Issue

Year

2011

Pages

Abstract

Old mice will have a subset of lesions as part of the progressive decline in organ function that defines aging. External and palpable lesions will be noted by the research, husbandry, or veterinary staff during testing, cage changing, or physical exams. While these readily observable lesions may cause alarm, not all cause undue distress or are life-threatening. In aging research, mice are maintained until near end of life that, depending on strain and genetic manipulation, can be upwards of 33 months. Aging research has unique welfare issues related to age-related decline, debilitation, fragility, and associated pain of chronic diseases. An effective aging research program includes the collaboration and education of the research, husbandry, and veterinary staff, and of the members of the institution animal care and use committee. This collaborative effort is critical to humanely maintaining older mice and preventing excessive censorship due to non-lethal diseases. Part of the educational process is becoming familiar with how old mice appear clinically, at necropsy and histopathologically. This baseline knowledge is important in making the determination of humane end points, defining health span, contributing causes of death and effects of interventions. The goal of this paper is to introduce investigators to age-associated diseases and lesion patterns in mice from clinical presentation to pathologic assessment. To do so, we present and illustrate the common clinical appearances, necropsy and histopathological lesions seen in subsets of the aging colonies maintained at the University of Washington.

Links

22953032 – National Library of Medicine/PubMed

Strain Notes

Strain Note
(BALB/c x C57BL/6)F1 These mice mice were from the colonies at the University of Washington.
C57BL/6J These mice were obtained from the Jackson Laboratory.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J Adrenal gland - Medulla pheochromocytoma - malignant Adrenal gland - Medulla

1

C57BL/6J Blood vessel hemangioma Spleen

1

C57BL/6J Blood vessel hemangiosarcoma Blood vessel

4

C57BL/6J Blood vessel hemangiosarcoma Spleen

observed

C57BL/6J Blood vessel hemangiosarcoma Uterus

observed

C57BL/6J Blood vessel hemangiosarcoma Ovary

observed

C57BL/6J Blood vessel hemangiosarcoma Liver

observed

C57BL/6J Blood vessel hemangiosarcoma Skin

observed

(BALB/c x C57BL/6)F1 Blood vessel hemangiosarcoma Skin

observed

C57BL/6J Bone - Vertebral column - Vertebra osteosarcoma Bone - Vertebral column - Vertebra

1

C57BL/6J Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

4

C57BL/6J Connective tissue - Fibroblast fibrosarcoma Uterus

observed

C57BL/6J Connective tissue - Fibroblast fibrosarcoma Skin

observed

C57BL/6J Connective tissue - Fibroblast fibrosarcoma Perirenal tissue

observed

C57BL/6J Connective tissue - Fibroblast fibrosarcoma Ear

observed

(BALB/c x C57BL/6)F1 Eye - Harderian gland adenoma Eye - Harderian gland

observed

C57BL/6J Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

observed

C57BL/6J Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus

observed

C57BL/6J Leukocyte lymphoma Leukocyte

observed

(BALB/c x C57BL/6)F1 Leukocyte lymphoma Spleen

observed

C57BL/6J Leukocyte neoplasia Leukocyte

67

C57BL/6J Liver adenoma Liver

1

C57BL/6J Liver cyst Liver

3

(BALB/c x C57BL/6)F1 Liver hepatocellular carcinoma Liver

observed

C57BL/6J Liver hyperplasia Liver

3

(BALB/c x C57BL/6)F1 Liver hyperplasia Liver

observed

C57BL/6J Lung adenocarcinoma Lung

3

(BALB/c x C57BL/6)F1 Lung adenocarcinoma Lung

observed

(BALB/c x C57BL/6)F1 Lung adenocarcinoma - mucinous Lung

observed

C57BL/6J Lung adenoma Lung

1

C57BL/6J Muscle - Smooth leiomyosarcoma Muscle - Smooth

3

C57BL/6J Muscle - Smooth leiomyosarcoma Seminal vesicle

4

C57BL/6J Muscle - Smooth leiomyosarcoma Intestine - Large Intestine - Colon

1

C57BL/6J Ovary - Granulosa cell tumor Ovary - Granulosa cell

2

C57BL/6J Ovary cyst Ovary

4

C57BL/6J Peritoneum - Mesentery hyperplasia Peritoneum - Mesentery

observed

C57BL/6J Pituitary gland - Pars distalis adenocarcinoma Pituitary gland - Pars distalis

1

C57BL/6J Pituitary gland adenoma Pituitary gland

6

(BALB/c x C57BL/6)F1 Preputial gland (male) cyst Preputial gland (male)

observed

C57BL/6J Skin squamous cell carcinoma Skin

1

C57BL/6J Stomach squamous cell papilloma Stomach

3

C57BL/6J Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

4

C57BL/6J Tooth dysplasia Tooth

observed

C57BL/6J Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

22