Reference SummaryHighman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30
Title |
Pathological changes in female C3H mice continuously fed diets containing diethylstilbestrol or 17beta--estradiol. |
Authors |
Highman B; Norvell MJ; Shellenberger TE |
Journal |
J Environ Pathol Toxicol |
Volume |
1 |
Issue |
1 |
Year |
1978 |
Pages |
1-30 |
Abstract |
To study the long term effects of estrogen administration in mice, virgin female C3H/HeJ mice are being fed diets containing 0, 10, 100 or 500 ppb of diethylstilbestrol (DES) or 0, 100, 1000, or 5000 pph of 17beta-estradiol (E2) from 6 to 110 weeks of age. C3HeB/FeJ mice are being fed diets containing 08 10, 100, or 500 ppb DES FROM 6 TO 136 WEEKS OF AGE. Pathologic studies were conducted on 396 such mice sacrificed at 52 weeks and on over 500 others sacrificed at various intervals. After 52 weeks on 500 ppb DES or 5000 ppb E2, the cervix of both populations often showed stromal mucoid changes and adenosis characterized by focal replacement of squamous by columnar epithelium lining the cervical canal assoicated with glandular downgrowths into the subjacent stroma. The uterine horns showed hyperplastic glands, which often penetrated the muscularis, and focal endometrial and perivascular hyalin deposits. The ovaries showed atrophy with absence of corpora lutea. Ceroid deposits were increased in the ovaries and adrenals. Sternal bony trabeculae were increased. The incidence of uterine cervical adenosis and of mammary hyperplastic alveolar nodules and tumors (mainly type B, Dunn's classification), was higher in C3H/HeJ than in C3HeB/FeJ mice. Mice on lower doses of DES or E2 had less frequent and severe similar changes. Tumors observed to date only in estrogen-treated mice included 4 endometrial adenocarcinomas and an adenoacanthoma of a uterine horn, 14 cervical adenocarcinomas often appearing to arise from areas of adenosis, a vaginal squamous cell carcinoma, a cervical granular cell myoblastoma, 1 sternal and 3 cranial osteosarcomas, and a mesothelioma. The majority of the malignancies occurred in C3H/HeJ mice. These findings indicate that the mammary tumor virus factor facilitates DES-induced mammary tumorigenesis in C3H mice and may contribute to other DES-induced malignant and premalignant lesions. |
Links |
J:237478 – MGI References 722180 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C3HeB/FeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
observed - 2.7 |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
observed |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
observed |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
3.12 |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
2.08 |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
2.86 |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
observed |
|
| C3H/HeJ | Bone - Skull osteosarcoma |
|
Bone - Skull |
observed |
|
| C3H/HeJ | Bone - Sternum hyperplasia |
|
Bone - Sternum |
observed |
|
| C3H/HeJ | Bone - Sternum osteosarcoma |
|
Bone - Sternum |
observed |
|
| C3H/HeJ | Bone - Sternum osteosarcoma |
|
Lung |
observed |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
0 |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
3.12 |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
2.63 |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
82 |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
0 |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
16 |
|
| C3H/HeJ | Bone hyperplasia |
|
Bone |
82 |
|
| C3HeB/FeJ | Bone hyperplasia |
|
Bone |
0 |
|
| C3HeB/FeJ | Bone hyperplasia |
|
Bone |
5.56 - 7.69 |
|
| C3HeB/FeJ | Bone hyperplasia |
|
Bone |
97.3 |
|
| C3H/HeJ | Intestine - Large Intestine - Rectum tumor |
|
Intestine - Large Intestine - Rectum |
observed |
|
| C3H/HeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
4.26 |
|
| C3H/HeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
0 - 7.89 |
|
| C3H/HeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
observed - 7 |
|
| C3H/HeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
0 |
|
| C3H/HeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
5.56 |
|
| C3H/HeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
8.33 |
|
| C3HeB/FeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
0 |
|
| C3HeB/FeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
0 |
|
| C3HeB/FeJ | Mammary gland adenocarcinoma |
|
Mammary gland |
0 |
|
| C3H/HeJ | Mammary gland adenocarcinoma - type A |
|
Mammary gland |
observed |
|
| C3H/HeJ | Mammary gland adenocarcinoma - type B |
|
Mammary gland |
observed |
|
| C3H/HeJ | Mammary gland adenocarcinoma - type B |
|
Mammary gland |
observed |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
0 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
3.12 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
5.26 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
14 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
0 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
2.78 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
9 |
|
| C3HeB/FeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
0 |
|
| C3HeB/FeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
0 |
|
| C3HeB/FeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
0 |
|
| C3H/HeJ | Mammary gland hyperplasia - alveolar |
|
Mammary gland |
observed |
|
| C3H/HeJ | Mammary gland tumor |
|
Mammary gland |
observed |
|
| C3HeB/FeJ | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3HeB/FeJ | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3H/HeJ | Mesothelium mesothelioma |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Muscle - Striated - Skeletal neoplasm - cystic |
|
Muscle - Striated - Skeletal |
observed |
|
| C3HeB/FeJ | Ovary - Germ cell teratoma |
|
Ovary - Germ cell |
observed |
|
| C3H/HeJ | Ovary - Granulosa cell tumor - granulosa cell |
|
Ovary - Granulosa cell |
observed |
|
| C3H/HeJ | Ovary - Granulosa cell tumor - granulosa cell |
|
Ovary - Granulosa cell |
observed |
|
| C3H/HeJ | Ovary - Luteal cell tumor |
|
Ovary - Luteal cell |
observed |
|
| C3H/HeJ | Ovary - Luteal cell tumor |
|
Ovary - Luteal cell |
observed |
|
| C3H/HeJ | Ovary adenoma - tubular |
|
Ovary |
observed |
|
| C3H/HeJ | Ovary adenoma - tubular |
|
Ovary |
observed |
|
| C3H/HeJ | Ovary cyst |
|
Ovary |
observed |
|
| C3H/HeJ | Ovary cyst |
|
Ovary |
observed |
|
| C3H/HeJ | Peritoneal cavity lesion - nodular |
|
Peritoneal cavity |
observed |
|
| C3H/HeJ | Urinary bladder cyst - glandular |
|
Urinary bladder |
observed |
|
| C3H/HeJ | Urinary bladder neoplasm - cystic |
|
Urinary bladder |
observed |
|
| C3H/HeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
5.26 |
|
| C3H/HeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
10.42 |
|
| C3H/HeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
2.86 |
|
| C3H/HeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
6.25 |
|
| C3HeB/FeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
5.56 |
|
| C3HeB/FeJ | Uterus - Cervix adenocarcinoma |
|
Uterus - Cervix |
5.41 |
|
| C3H/HeJ | Uterus - Cervix atypia - glandular |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix cyst - glandular |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix cyst - papillary |
|
Uterus - Cervix |
observed |
|
| C3HeB/FeJ | Uterus - Cervix hyperplasia |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
0 - 36 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
0 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
9 - 14 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
0 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
33 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
observed - 89 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
15 - 17.14 |
|
| C3H/HeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
29.17 |
|
| C3HeB/FeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
0 - 11.11 |
|
| C3HeB/FeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
12.82 - 45.95 |
|
| C3HeB/FeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
0 - 61.11 |
|
| C3HeB/FeJ | Uterus - Cervix lesion |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix myoblastoma - granular cell |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix neoplasia |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix neoplasia - glandular |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix neoplasia - glandular |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix neoplasm - cystic |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix tumor |
|
Uterus - Cervix |
observed |
|
| C3H/HeJ | Uterus - Cervix tumor |
|
Muscle - Striated - Skeletal |
observed |
|
| C3H/HeJ | Uterus - Endometrium hyperplasia |
|
Uterus - Endometrium |
observed |
|
| C3HeB/FeJ | Uterus - Endometrium hyperplasia |
|
Uterus - Endometrium |
observed |
|
| C3H/HeJ | Uterus - Uterine gland cyst - glandular |
|
Uterus - Uterine gland |
observed |
|
| C3H/HeJ | Uterus - Uterine gland hyperplasia |
|
Uterus - Uterine gland |
observed |
|
| C3H/HeJ | Uterus - Uterine gland neoplasia |
|
Uterus - Uterine gland |
observed |
|
| C3H/HeJ | Uterus - Uterine gland neoplasia |
|
Uterus - Uterine gland |
observed |
|
| C3H/HeJ | Uterus - Uterine gland neoplasia |
|
Uterus - Uterine gland |
observed |
|
| C3H/HeJ | Uterus - Uterine gland neoplasm - cystic |
|
Uterus - Uterine gland |
observed |
|
| C3H/HeJ | Uterus - Uterine horn adenoacanthoma |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn adenoacanthoma |
|
Uterus - Uterine horn |
2.08 |
|
| C3H/HeJ | Uterus - Uterine horn adenocarcinoma |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn adenocarcinoma |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn adenocarcinoma |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn adenocarcinoma |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn adenocarcinoma |
|
Uterus - Uterine horn |
2.63 - 3.12 |
|
| C3H/HeJ | Uterus - Uterine horn adenocarcinoma |
|
Uterus - Uterine horn |
4.17 |
|
| C3H/HeJ | Uterus - Uterine horn atypia |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
25.53 |
|
| C3H/HeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
15.62 |
|
| C3H/HeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
78.95 |
|
| C3H/HeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
100 |
|
| C3H/HeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
24 - 95.83 |
|
| C3H/HeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
62 |
|
| C3HeB/FeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
11.11 |
|
| C3HeB/FeJ | Uterus - Uterine horn hyperplasia - glandular |
|
Uterus - Uterine horn |
5.13 - 94.59 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
2.13 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
3.12 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
46 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
93 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
5.71 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
5.56 |
|
| C3H/HeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
81.25 |
|
| C3HeB/FeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
16.67 |
|
| C3HeB/FeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
5.13 |
|
| C3HeB/FeJ | Uterus - Uterine horn lesion |
|
Uterus - Uterine horn |
33.33 - 86.49 |
|
| C3H/HeJ | Uterus - Uterine horn neoplasia |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn neoplasia |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn neoplasia - glandular |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn neoplasia - glandular |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn tumor |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus - Uterine horn tumor |
|
Uterus - Uterine horn |
observed |
|
| C3H/HeJ | Uterus lesion - nodular |
|
Uterus |
observed |
|
| C3H/HeJ | Vagina lesion |
|
Vagina |
observed |
|
| C3HeB/FeJ | Vagina squamous cell carcinoma |
|
Vagina |
observed |
|
| C3HeB/FeJ | Vagina squamous cell carcinoma |
|
Vagina |
2.7 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
0 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
6.25 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
7.89 - 12.5 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
5.71 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
0 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
10.42 |
|
| C3HeB/FeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
0 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
0 - 10.81 |
|
| C3H/HeJ | (Unspecified organ) tumor - malignant |
|
(Unspecified organ) |
5.56 |