Reference SummaryAkamatsu Y, J Natl Cancer Inst 1975 Oct;55(4):893-7

Title

Neoplasms in strains of splenectomized mice after a single 7,12-dimethylbenz[alpha]anthracene treatment.

Authors

Akamatsu Y

Journal

J Natl Cancer Inst

Volume

55

Issue

4

Year

1975

Pages

893-7

Abstract

The effects of splenectomy on carcinogenesis by a single 10-mg dose of 7,12-dimethylbenz[alpha]anthracene (DMBA) given in olive oil by gavage was tested on BTOs, C57BL/60s, C3H/HeOs, and BALB/cOs mice. The splenectomy, performed a week before the DMBA was given, did not affect physical status or the incidence of acute toxic death of animals. DMBA-treated animals developed neoplasms at a significantly higher rate than did untreated mice. Splenectomy did not influence the overall incidence of neoplasms. Observed tumors in DMBA-treated groups were those of skin, forestomach, colon, liver, lung, adrenal, ovary, breast, hematopoietic-lymphoreticular system, and vascular system, depending on the strain. Types of DMBA-treated neoplasms were affected by prior splenectomy, depending on the strain: Splenectomy inhibited lung adenomas in BALB/cOs females and hepatomas in C57BL/60s females; splenectomy enhanced skin neoplasms in C57BL/60s and squamous cell carcinoma of the forestomach in BTOs males. The most significant change was in the incidence of the group of lymphomas. Myelogenous leukemia was increased in DMBA-treated groups of all strains, but splenectomy inhibited the development of this type of lymphoma.

Links

171427 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C3H/HeOs Adrenal gland - Medulla carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland - Medulla

3.8

BT/Os Adrenal gland tumor Adrenal gland

0

BT/Os Adrenal gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

BT/Os Adrenal gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

C57BL/6Os Adrenal gland tumor Adrenal gland

0

C57BL/6Os Adrenal gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

C57BL/6Os Adrenal gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

C3H/HeOs Adrenal gland tumor Adrenal gland

0

C3H/HeOs Adrenal gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

C3H/HeOs Adrenal gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

BALB/cOs Adrenal gland tumor Adrenal gland

0

BALB/cOs Adrenal gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

BALB/cOs Adrenal gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Adrenal gland

0

BT/Os Blood vessel hemangioma Blood vessel

0

BT/Os Blood vessel hemangioma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

0

BT/Os Blood vessel hemangioma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

0

C57BL/6Os Blood vessel hemangioma Blood vessel

0

C57BL/6Os Blood vessel hemangioma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

13 - 22

C57BL/6Os Blood vessel hemangioma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

9.1 - 25

C3H/HeOs Blood vessel hemangioma Blood vessel

0

C3H/HeOs Blood vessel hemangioma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

0 - 15

C3H/HeOs Blood vessel hemangioma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

0 - 19

BALB/cOs Blood vessel hemangioma Blood vessel

0

BALB/cOs Blood vessel hemangioma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

23

BALB/cOs Blood vessel hemangioma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

18

BT/Os Forestomach keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0 - 5.6

BT/Os Forestomach keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

4.5 - 8.7

C57BL/6Os Forestomach keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

7.4 - 9.7

C57BL/6Os Forestomach keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

12 - 12.5

C3H/HeOs Forestomach keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0 - 5.1

C3H/HeOs Forestomach keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0 - 7.7

BALB/cOs Forestomach keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0

BALB/cOs Forestomach keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

5.9

BT/Os Forestomach squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

5.6 - 6.3

BT/Os Forestomach squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

4.5 - 22

C57BL/6Os Forestomach squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0 - 7.4

C57BL/6Os Forestomach squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0 - 3.0

C3H/HeOs Forestomach squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0 - 15

C3H/HeOs Forestomach squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0

BALB/cOs Forestomach squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

6.5

BALB/cOs Forestomach squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

0

BT/Os Forestomach squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

6.3 - 22

BT/Os Forestomach squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

9.1 - 22

C57BL/6Os Forestomach squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

26 - 35

C57BL/6Os Forestomach squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

45 - 62.5

C3H/HeOs Forestomach squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

20 - 21

C3H/HeOs Forestomach squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

6.3 - 19

BALB/cOs Forestomach squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

35

BALB/cOs Forestomach squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Forestomach

5.9

BT/Os Forestomach tumor Forestomach

0

C57BL/6Os Forestomach tumor Forestomach

0

C3H/HeOs Forestomach tumor Forestomach

0

BALB/cOs Forestomach tumor Forestomach

0

C57BL/6Os Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

7.4

C3H/HeOs Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

2.6

C3H/HeOs Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

7.7

BT/Os Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

BT/Os Intestine - Large Intestine - Colon tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

BT/Os Intestine - Large Intestine - Colon tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

C57BL/6Os Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

C57BL/6Os Intestine - Large Intestine - Colon tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

C57BL/6Os Intestine - Large Intestine - Colon tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

C3H/HeOs Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

C3H/HeOs Intestine - Large Intestine - Colon tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

C3H/HeOs Intestine - Large Intestine - Colon tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

BALB/cOs Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

BALB/cOs Intestine - Large Intestine - Colon tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

BALB/cOs Intestine - Large Intestine - Colon tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Intestine - Large Intestine - Colon

0

BT/Os Leukocyte - Lymphocyte leukemia - lymphocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Lymphocyte

17

BT/Os Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

2

C57BL/6Os Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

2.3 - 6.3

C57BL/6Os Leukocyte - Lymphocyte leukemia - lymphocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Lymphocyte

7.4 - 13

C57BL/6Os Leukocyte - Lymphocyte leukemia - lymphocytic
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Lymphocyte

0 - 3.0

C3H/HeOs Leukocyte - Lymphocyte leukemia - lymphocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Lymphocyte

0

BALB/cOs Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

3.3

BALB/cOs Leukocyte - Lymphocyte leukemia - lymphocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Lymphocyte

16

BALB/cOs Leukocyte - Lymphocyte leukemia - lymphocytic
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Lymphocyte

18

BT/Os Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Monocyte - Macrophage - Histiocyte

17

BT/Os Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0

C57BL/6Os Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0

C57BL/6Os Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Monocyte - Macrophage - Histiocyte

3.2 - 11

C57BL/6Os Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Monocyte - Macrophage - Histiocyte

12 - 37.5

C3H/HeOs Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 10

BALB/cOs Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0

BALB/cOs Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Monocyte - Macrophage - Histiocyte

9.7

BALB/cOs Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Monocyte - Macrophage - Histiocyte

0

BT/Os Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Myelocyte (Granulocyte)

17

BT/Os Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

2

C57BL/6Os Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

C57BL/6Os Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Myelocyte (Granulocyte)

0 - 26

C57BL/6Os Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Myelocyte (Granulocyte)

0

C3H/HeOs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Myelocyte (Granulocyte)

0 - 5.1

BALB/cOs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

BALB/cOs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Myelocyte (Granulocyte)

3.2

BALB/cOs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte - Myelocyte (Granulocyte)

0

BT/Os Leukocyte lymphoma Leukocyte

0

BT/Os Leukocyte lymphoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

0

BT/Os Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

0

C3H/HeOs Leukocyte lymphoma Leukocyte

0

C3H/HeOs Leukocyte lymphoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

0

BT/Os Liver hepatoma Liver

0 - 8

BT/Os Liver hepatoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0 - 28

BT/Os Liver hepatoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0 - 8.7

C57BL/6Os Liver hepatoma Liver

0

C57BL/6Os Liver hepatoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0 - 15

C57BL/6Os Liver hepatoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0 - 12.5

C3H/HeOs Liver hepatoma Liver

0 - 12.5

C3H/HeOs Liver hepatoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0 - 36

C3H/HeOs Liver hepatoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0 - 15

BALB/cOs Liver hepatoma Liver

0

BALB/cOs Liver hepatoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

13

BALB/cOs Liver hepatoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Liver

0

BT/Os Lung adenoma Lung

0

BT/Os Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

0 - 5.6

BT/Os Lung adenoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

4.3 - 4.5

C57BL/6Os Lung adenoma Lung

1.6 - 2.3

C57BL/6Os Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

0 - 13

C57BL/6Os Lung adenoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

12 - 25

C3H/HeOs Lung adenoma Lung

0

C3H/HeOs Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

0 - 7.7

C3H/HeOs Lung adenoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

0 - 3.8

BALB/cOs Lung adenoma Lung

1.6

BALB/cOs Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

35

BALB/cOs Lung adenoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

0

BT/Os Mammary gland adenoacanthoma Mammary gland

0

BT/Os Mammary gland adenoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BT/Os Mammary gland adenoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C57BL/6Os Mammary gland adenoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C3H/HeOs Mammary gland adenoacanthoma Mammary gland

0

C3H/HeOs Mammary gland adenoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C3H/HeOs Mammary gland adenoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BALB/cOs Mammary gland adenoacanthoma Mammary gland

0

BALB/cOs Mammary gland adenoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

19

BALB/cOs Mammary gland adenoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

5.9

BT/Os Mammary gland adenocarcinoma Mammary gland

58

BT/Os Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

69

BT/Os Mammary gland adenocarcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

86

C57BL/6Os Mammary gland adenocarcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C3H/HeOs Mammary gland adenocarcinoma Mammary gland

74

C3H/HeOs Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

90

C3H/HeOs Mammary gland adenocarcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

81

BALB/cOs Mammary gland adenocarcinoma Mammary gland

3.3

BALB/cOs Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

19

BALB/cOs Mammary gland adenocarcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

41

BT/Os Mammary gland adenoma - fibroid Mammary gland

0

BT/Os Mammary gland adenoma - fibroid
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

6.3

BT/Os Mammary gland adenoma - fibroid
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C57BL/6Os Mammary gland adenoma - fibroid
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

3.0

C3H/HeOs Mammary gland adenoma - fibroid Mammary gland

0

C3H/HeOs Mammary gland adenoma - fibroid
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C3H/HeOs Mammary gland adenoma - fibroid
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BALB/cOs Mammary gland adenoma - fibroid Mammary gland

0

BALB/cOs Mammary gland adenoma - fibroid
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BALB/cOs Mammary gland adenoma - fibroid
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C57BL/6Os Mammary gland tumor Mammary gland

0

C57BL/6Os Mammary gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BT/Os Mammary gland tumor Mammary gland

0

BT/Os Mammary gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BT/Os Mammary gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C57BL/6Os Mammary gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C3H/HeOs Mammary gland tumor Mammary gland

0

C3H/HeOs Mammary gland tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

C3H/HeOs Mammary gland tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

0

BT/Os Mesodermal cell/mesoblast sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 5.6

BT/Os Mesodermal cell/mesoblast sarcoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

C57BL/6Os Mesodermal cell/mesoblast sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

C57BL/6Os Mesodermal cell/mesoblast sarcoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 12.5

C3H/HeOs Mesodermal cell/mesoblast sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

5.1

C3H/HeOs Mesodermal cell/mesoblast sarcoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

BALB/cOs Mesodermal cell/mesoblast sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

3.2

BALB/cOs Mesodermal cell/mesoblast sarcoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

5.9

BT/Os Ovary tumor Ovary

0

BT/Os Ovary tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

6.3

BT/Os Ovary tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

4.5

C57BL/6Os Ovary tumor Ovary

1.6

C57BL/6Os Ovary tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

11

C57BL/6Os Ovary tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

3.0

C3H/HeOs Ovary tumor Ovary

8.6

C3H/HeOs Ovary tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

0

C3H/HeOs Ovary tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

0

BALB/cOs Ovary tumor Ovary

1.6

BALB/cOs Ovary tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

13

BALB/cOs Ovary tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

12

BT/Os Skin keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

5.6 - 6.3

BT/Os Skin keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
  • splenectomy
Skin

13

BT/Os Skin keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

9.1

C57BL/6Os Skin keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

13 - 30

C57BL/6Os Skin keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

33 - 37.5

C3H/HeOs Skin keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

C3H/HeOs Skin keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

3.8

BALB/cOs Skin keratoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

13

BALB/cOs Skin keratoacanthoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

BT/Os Skin squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 17

BT/Os Skin squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 13

C57BL/6Os Skin squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 3.7

C57BL/6Os Skin squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

3.0 - 12.5

C3H/HeOs Skin squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

10

C3H/HeOs Skin squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

12

BALB/cOs Skin squamous cell carcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

3.2

BALB/cOs Skin squamous cell carcinoma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

BT/Os Skin squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

5.6 - 12.5

BT/Os Skin squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 4.3

C57BL/6Os Skin squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0 - 16

C57BL/6Os Skin squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

12.5 - 18

C3H/HeOs Skin squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

21

C3H/HeOs Skin squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

23

BALB/cOs Skin squamous cell papilloma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

16

BALB/cOs Skin squamous cell papilloma
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

5.9

BT/Os Skin tumor Skin

0

C57BL/6Os Skin tumor Skin

0

C3H/HeOs Skin tumor Skin

0

C3H/HeOs Skin tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

C3H/HeOs Skin tumor
  • splenectomy
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Skin

0

BALB/cOs Skin tumor Skin

0