Reference SummarySearle CE, Br J Cancer 1966 Dec;20(4):877-85

Title

 Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin.

Authors

 Searle CE; Spencer AT

Journal

 Br J Cancer

Volume

 20

Issue

 4

Year

 1966

Pages

 877-85

Abstract

Links

 J:25337 – MGI References
5964618 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/Bcr Connective tissue - Fibroblast fibroma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue - Fibroblast

observed
C57BL/Bcr Connective tissue neoplasm
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

observed
Swiss Connective tissue tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

0 - 6.67
(C57BL/Bcr x IF/Bcr)F1 Connective tissue tumor
  • Bemax
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

6.67
NZY/Bcr Connective tissue tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

6.67
C57BL/Bcr Connective tissue tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

observed
A/Bcr Connective tissue tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

0 - observed
IF/Bcr Connective tissue tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

0
(C57BL/Bcr x IF/Bcr)F1 Connective tissue tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

observed
C57BL/Bcr Connective tissue tumor - giant cell
  • 4-nitroquinoline-N-oxide (4-NQO)
 Connective tissue

observed
Swiss Lung adenocarcinoma - papillary
  • 4-nitroquinoline-N-oxide (4-NQO)
 Lung

6.67
A/Bcr Mesodermal cell/mesoblast sarcoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
(C57BL/Bcr x IF/Bcr)F1 Mesodermal cell/mesoblast sarcoma
  • Bemax
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

6.67
NZY/Bcr Mesodermal cell/mesoblast sarcoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

6.67
A/Bcr Mesodermal cell/mesoblast sarcoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Mesodermal cell/mesoblast

0
(C57BL/Bcr x IF/Bcr)F1 Mesodermal cell/mesoblast sarcoma - pleomorphic
  • 4-nitroquinoline-N-oxide (4-NQO)
 Mesodermal cell/mesoblast

observed
Swiss Mesodermal cell/mesoblast sarcoma - spindle cell
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin - Dermis

6.67
NZY/Bcr Mesodermal cell/mesoblast sarcoma - spindle cell
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

6.67
C57BL/Bcr Mesodermal cell/mesoblast sarcoma - spindle cell
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
A/Bcr Mesodermal cell/mesoblast sarcoma - spindle cell
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

26.67
NZY/Bcr Skin - Epidermis - Basal cell acanthoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin - Epidermis - Basal cell

observed
NZY/Bcr Skin - Hair follicle - Basal cell trichoepithelioma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin - Hair follicle - Basal cell

6.67
Swiss Skin keratoacanthoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

6.67
NZY/Bcr Skin keratoacanthoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
Swiss Skin papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed - 6.67
(C57BL/Bcr x IF/Bcr)F1 Skin papilloma
  • Bemax
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0 - observed
NZY/Bcr Skin papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
C57BL/Bcr Skin papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
A/Bcr Skin papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
IF/Bcr Skin papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
(C57BL/Bcr x IF/Bcr)F1 Skin papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
Swiss Skin squamous cell carcinoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0 - 6.67
(C57BL/Bcr x IF/Bcr)F1 Skin squamous cell carcinoma
  • Bemax
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0 - 13.33
NZY/Bcr Skin squamous cell carcinoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
C57BL/Bcr Skin squamous cell carcinoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
A/Bcr Skin squamous cell carcinoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0 - 6.67
IF/Bcr Skin squamous cell carcinoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
(C57BL/Bcr x IF/Bcr)F1 Skin squamous cell carcinoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
NZY/Bcr Skin squamous cell carcinoma - well differentiated
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
C57BL/Bcr Skin squamous cell carcinoma - well differentiated
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

observed
NZY/Bcr Skin squamous cell papilloma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

6.67
NZY/Bcr Skin tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

86.67
C57BL/Bcr Skin tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

66.67 - 69.23
Swiss Skin tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

33.33
A/Bcr Skin tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

40
(C57BL/Bcr x IF/Bcr)F1 Skin tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

20
IF/Bcr Skin tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
A/Bcr Skin tumor - epithelial
  • 4-nitroquinoline-N-oxide (4-NQO)
 Skin

0
A/Bcr (Unspecified organ) reticulum cell sarcoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Spleen

6.67
A/Bcr (Unspecified organ) reticulum cell sarcoma
  • 4-nitroquinoline-N-oxide (4-NQO)
 Lymph node - Mesenteric

6.67