Reference SummaryMucenski ML, J Virol 1988 Mar;62(3):839-46

Title

Comparative molecular genetic analysis of lymphomas from six inbred mouse strains.

Authors

Mucenski ML; Bedigian HG; Shull MM; Copeland NG; Jenkins NA

Journal

J Virol

Volume

62

Issue

3

Year

1988

Pages

839-46

Abstract

Previous studies of 21 highly lymphomatous AKXD recombinant inbred mouse strains demonstrated correlations between lymphoma type, the somatic proviral DNA content of the lymphoma, and the frequency of virally induced rearrangements in eight common sites of viral integration (Myc, Pim-i, Pvt-1, Mlvi-1, Mlvi-2, Fis-1, Myb, and Evi-1). In this study we analyzed lymphomas from six inbred mouse strains, AKR/J, C58/J, HRS/J (hr/hr and hr/+), SJL/J, SEA/GnJ, and CWD/LeAgl, to determine whether these correlations are also evident in these strains. Mice of the AKR/J, C58/J, and HRS/J strains died exclusively of T-cell lymphomas. In contrast to earlier studies which showed a great disparity in the rate and incidence of lymphomas in HRS/J hr/hr and HRS/J hr/+ mice, we found a high incidence of T-cell lymphomas and the same mean age of onset of disease in both strains. SJL/J mice died primarily of pre-B-cell lymphomas, whereas CWD/LeAgl and SEA/GnJ mice died primarily of B-cell lymphomas. Somatically acquired mink cell focus-forming proviruses were detected only in T-cell lymphomas, whereas ecotropic proviruses were found in lymphomas from all hematopoietic cell lineages. No rearrangements were detected in the Fis-1, Mlvi-2, and Myb loci, whereas rearrangements were detected in the Mlvi-1, Myc, Pim-1, Pvt-1, and Evi-1 loci. Most rearrangements were found in T-cell lymphomas, and many were virally induced. These results are similar to those we obtained previously for lymphomas of 21 highly lymphomatous AKXD recombinant inbred mouse strains.

Links

2828679 – National Library of Medicine/PubMed

Strain Notes

Strain Note
HRS/J These mice were from The Jackson Laboratory.
HRS/J These mice were from The Jackson Laboratory.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
SJL/J Hematopoietic stem cell lymphoma Hematopoietic stem cell

observed

CWD/LeAgl Hematopoietic stem cell lymphoma Hematopoietic stem cell

observed

SEA/GnJ Hematopoietic stem cell lymphoma Hematopoietic stem cell

observed

SJL/J Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte

observed

CWD/LeAgl Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte

observed

SEA/GnJ Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte

observed

SJL/J Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma Leukocyte - Lymphocyte - Pre-B-lymphocyte

observed

CWD/LeAgl Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma Leukocyte - Lymphocyte - Pre-B-lymphocyte

observed

C58/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

observed

AKR/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

observed

HRS/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

observed

HRS/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

observed

CWD/LeAgl Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

observed

SEA/GnJ Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

observed

CWD/LeAgl Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

observed