Reference SummaryAnderson LM, Cancer Lett 1990 Jul 16;52(2):91-4

Title

Effect of pretreatment with beta-naphthoflavone on tumorigenesis by N-nitrosoethylurea in five mouse strains.

Authors

Anderson LM; Jones AB; Kovatch RM

Journal

Cancer Lett

Volume

52

Issue

2

Year

1990

Pages

91-4

Abstract

The non-carcinogenic inducer of the Ah locus, beta-naphthoflavone (beta NF), was administered to females of 5 mouse strains at a dose of 150 mg/kg 48 h before treatment with a tumorigenic dose of the direct-acting carcinogen, N-nitrosoethylurea (ENU), once weekly for 4 weeks. The strains used were C57BL/6, C3H/He and NIH Swiss (responsive to Ah locus induction) and AKR and DBA/2 (induction-non-responsive). The ENU caused primary lung tumors in all strains and in some cases smaller numbers of other neoplasms, including lymphomas, sarcomas and hepatocellular tumors. The beta NF pretreatment did not reduce the numbers of any of the tumors, compared with mice given ENU alone. This result is in contrast to previous findings of a strong protective effect of beta NF against tumorigenesis in Ah-responsive strains by the metabolism-dependent carcinogens, benzo[a]pyrene and 3-methylcholanthrene and confirms that this protection is directly related to enzyme induction. beta NF treatment caused a significant doubling in the number of lung tumor bearers among the ENU-exposed C57BL/6 mice but in no other strain, suggesting the possibility of strain-specific tumor promotion.

Links

2379139 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6NCr Blood vessel hemangiosarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Blood vessel

2.9

Swiss/N Blood vessel hemangiosarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Blood vessel

11

AKR/NCr Blood vessel hemangiosarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Blood vessel

3.1

C57BL/6NCr Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Leukocyte - Monocyte - Macrophage - Histiocyte

2.9

DBA/2NCr Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Leukocyte - Monocyte - Macrophage - Histiocyte

5.9

C57BL/6NCr Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Leukocyte

2.9

C57BL/6NCr Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Leukocyte

6.9

C57BL/6NCr Leukocyte lymphoma Leukocyte

7.7

C3H/HeNCr Leukocyte lymphoma
  • beta-naphthoflavone (betaNF)
Leukocyte

6.3

Swiss/N Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Leukocyte

7.4

Swiss/N Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Leukocyte

6.3

DBA/2NCr Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Leukocyte

24

DBA/2NCr Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Leukocyte

21

AKR/NCr Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Leukocyte

94

AKR/NCr Leukocyte lymphoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Leukocyte

94

AKR/NCr Leukocyte lymphoma
  • beta-naphthoflavone (betaNF)
Leukocyte

100

AKR/NCr Leukocyte lymphoma Leukocyte

100

C57BL/6NCr Liver hepatocellular adenoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Liver

2.9

C3H/HeNCr Liver hepatocellular adenoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Liver

6.9

C3H/HeNCr Liver hepatocellular adenoma Liver

6.7

C3H/HeNCr Liver hepatocellular carcinoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Liver

3.0

C57BL/6NCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Lung

26

C3H/HeNCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Lung

79

Swiss/N Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Lung

96

DBA/2NCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Lung

35

AKR/NCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Lung

25

C57BL/6NCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Lung

59

C3H/HeNCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Lung

86

Swiss/N Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Lung

75

DBA/2NCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Lung

44

AKR/NCr Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Lung

23

C57BL/6NCr Lung tumor
  • beta-naphthoflavone (betaNF)
Lung

0

C3H/HeNCr Lung tumor
  • beta-naphthoflavone (betaNF)
Lung

6.3

Swiss/N Lung tumor
  • beta-naphthoflavone (betaNF)
Lung

31

DBA/2NCr Lung tumor
  • beta-naphthoflavone (betaNF)
Lung

20

AKR/NCr Lung tumor
  • beta-naphthoflavone (betaNF)
Lung

5.3

C57BL/6NCr Lung tumor Lung

0

C3H/HeNCr Lung tumor Lung

6.7

Swiss/N Lung tumor Lung

17

DBA/2NCr Lung tumor Lung

6.7

AKR/NCr Lung tumor Lung

14

C3H/HeNCr Muscle - Smooth leiomyosarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Muscle - Smooth

3.4

Swiss/N Muscle - Striated - Skeletal rhabdomyosarcoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Muscle - Striated - Skeletal

6.3

C3H/HeNCr Ovary - Germ cell teratoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Ovary - Germ cell

3.4

C3H/HeNCr Ovary tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
  • beta-naphthoflavone (betaNF)
Ovary

3.4