Reference SummaryFrith CH, Lab Anim Sci 1983 Jun;33(3):273-86

Title

Spontaneous lesions in virgin and retired breeder BALB/c and C57BL/6 mice.

Authors

Frith CH; Highman B; Burger G; Sheldon WD

Journal

Lab Anim Sci

Volume

33

Issue

3

Year

1983

Pages

273-86

Abstract

Prevalences of neoplastic and nonneoplastic lesions were reported for 3,000 virgin and 800 retired breeder BALB/c and C57BL/6 mice, untreated and of both sexes. The most common nonneoplastic lesions in the BALB/c mice were: hepatic fatty metamorphosis, uterine hemosiderosis and mineralization, testicular atrophy, ovarian cysts, and adrenal subcapsular spindle cell hyperplasia. The most common neoplasms in the BALB/c mice were: pulmonary tumors, hepatocellular neoplasms, Harderian adenomas, and uterine polyps. Common nonneoplastic lesions in the C57BL/6 mice were: pulmonary lymphoid accumulations, hepatic fatty metamorphosis, multifocal aggregates of mononuclear cells in the liver, proteinaceous renal casts, uterine hemosiderosis, endometrial cystic hyperplasia, ovarian atrophy, ovarian cysts, and pituitary cysts. The most common neoplasms in the C57BL/6 mice were angiosarcomas and pituitary adenomas. Hematopoietic tumors were common in both strains.

Links

J:27148 – MGI References
6876733 – National Library of Medicine/PubMed

Strain Notes

Strain Note
BALB/cStCrlfC3Hf/Nctr This reference lists this strain as BALB/cStCrlfC3H/Nctr but based on the reference's lack of reported mammary gland tumors for either sex of this strain the reported strain name is believed to be a typographical error.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/cStCrlfC3Hf/Nctr Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 8.0

C57BL/6JfC3Hf/Nctr Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 0.6

BALB/cStCrlfC3Hf/Nctr Adrenal gland - Cortex carcinoma Adrenal gland - Cortex

observed

C57BL/6JfC3Hf/Nctr Adrenal gland - Cortex carcinoma Adrenal gland - Cortex

observed

BALB/cStCrlfC3Hf/Nctr Adrenal gland - Cortex hyperplasia Adrenal gland - Cortex

0 - 16

C57BL/6JfC3Hf/Nctr Adrenal gland - Cortex hyperplasia Adrenal gland - Cortex

0

BALB/cStCrlfC3Hf/Nctr CNS - Brain - Astrocyte astrocytoma CNS - Brain - Astrocyte

observed

BALB/cStCrlfC3Hf/Nctr Erythrocyte hyperplasia Spleen

0 - 6.8

C57BL/6JfC3Hf/Nctr Erythrocyte hyperplasia Spleen

0 - 7.9

BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland adenoma Eye - Harderian gland

0 - 14

C57BL/6JfC3Hf/Nctr Eye - Harderian gland adenoma Eye - Harderian gland

0 - 4.9

BALB/cStCrlfC3Hf/Nctr Eye - Lacrimal gland hyperplasia - ductal Eye - Lacrimal gland

0 - 11

C57BL/6JfC3Hf/Nctr Eye - Lacrimal gland hyperplasia - ductal Eye - Lacrimal gland

0 - 20

BALB/cStCrlfC3Hf/Nctr Eye - Lacrimal gland tumor Eye - Lacrimal gland

0

C57BL/6JfC3Hf/Nctr Eye - Lacrimal gland tumor Eye - Lacrimal gland

0

C57BL Intestine - Small Intestine - Duodenum polyp Intestine - Small Intestine - Duodenum

observed

C57BL/6JfC3Hf/Nctr Intestine polyp Intestine

0 - 1.6

BALB/cStCrlfC3Hf/Nctr Intestine polyp Intestine

0 - 3.2

C57BL Intestine tumor Intestine

observed

BALB/cStCrlfC3Hf/Nctr Kidney - Cortex metaplasia - osseous Kidney - Cortex

1

C57BL/6JfC3Hf/Nctr Kidney - Cortex metaplasia - osseous Kidney - Cortex

1

BALB/cStCrlfC3Hf/Nctr Kidney adenocarcinoma Kidney

0 - 1.7

BALB/cStCrlfC3Hf/Nctr Kidney adenoma Kidney

0 - 1.1

C57BL/6JfC3Hf/Nctr Kidney tumor Kidney

0

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte

0 - 27

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte

0 - 28

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte hyperplasia Spleen

0 - 11

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte hyperplasia Spleen

0 - 8.0

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte lymphoma - lymphocytic Leukocyte - Lymphocyte

0 - 6.7

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte lymphoma - lymphocytic Leukocyte - Lymphocyte

0 - 3.6

BALB/cStCrlfC3Hf/Nctr Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 1.7

C57BL/6JfC3Hf/Nctr Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 5.5

C57BL/6JfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell sarcoma - mast cell Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

observed

BALB/cStCrlfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 7.1

C57BL/6JfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 8.8

BALB/cStCrlfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

observed

C57BL/6JfC3Hf/Nctr Liver hepatocellular carcinoma Liver

observed

BALB/cStCrlfC3Hf/Nctr Liver hepatocellular tumor Liver

0 - 11

C57BL/6JfC3Hf/Nctr Liver hepatocellular tumor Liver

0 - 4.7

BALB/cStCrlfC3Hf/Nctr Lung tumor Lung

0 - 42

C57BL/6JfC3Hf/Nctr Lung tumor Lung

0 - 6.1

BALB/cStCrlfC3Hf/Nctr Mammary gland adenocarcinoma Mammary gland

0 - 2.7

C57BL/6JfC3Hf/Nctr Mammary gland tumor Mammary gland

0

BALB/cStCrlfC3Hf/Nctr Muscle - Smooth leiomyoma Uterus

observed

C57BL/6JfC3Hf/Nctr Myoepithelial cell myoepithelioma Salivary gland

0

BALB/cStCrlfC3Hf/Nctr Myoepithelial cell myoepithelioma Salivary gland

0 - 1.2

BALB/c Myoepithelial cell myoepithelioma Salivary gland - Parotid

observed

C3H/HeN Myoepithelial cell myoepithelioma Salivary gland - Parotid

observed

BALB/cStCrlfC3Hf/Nctr Ovary - Granulosa cell tumor Ovary - Granulosa cell

0 - 1.6

C57BL/6JfC3Hf/Nctr Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

BALB/cStCrlfC3Hf/Nctr Ovary adenoma - tubular Ovary

0 - 0.5

C57BL/6JfC3Hf/Nctr Ovary adenoma - tubular Ovary

0 - 3.7

BALB/cStCrlfC3Hf/Nctr Ovary luteoma Ovary

0 - 0.8

C57BL/6JfC3Hf/Nctr Ovary luteoma Ovary

0

BALB/cStCrlfC3Hf/Nctr PNS - Schwann cell myoblastoma - granular cell Epididymis

7.0

BALB/cStCrlfC3Hf/Nctr Pituitary gland adenoma Pituitary gland

0

C57BL/6JfC3Hf/Nctr Pituitary gland adenoma Pituitary gland

0 - 11

BALB/cStCrlfC3Hf/Nctr Reticular cell hyperplasia Spleen

0 - 5.4

C57BL/6JfC3Hf/Nctr Reticular cell hyperplasia Spleen

0 - 6.9

C57BL/6JfC3Hf/Nctr Salivary gland - Parotid hyperplasia - ductal Salivary gland - Parotid

0 - 4.2

BALB/cStCrlfC3Hf/Nctr Salivary gland - Parotid hyperplasia - ductal Salivary gland - Parotid

0 - 3.8

C57BL/6JfC3Hf/Nctr Salivary gland - Sublingual hyperplasia - ductal Salivary gland - Sublingual

0

BALB/cStCrlfC3Hf/Nctr Salivary gland - Sublingual hyperplasia - ductal Salivary gland - Sublingual

0 - 2

C57BL/6JfC3Hf/Nctr Salivary gland - Submandibular hyperplasia - ductal Salivary gland - Submandibular

0 - 5.3

BALB/cStCrlfC3Hf/Nctr Salivary gland - Submandibular hyperplasia - ductal Salivary gland - Submandibular

0 - 7.6

BALB/cStCrlfC3Hf/Nctr Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0 - 1.7

C57BL/6JfC3Hf/Nctr Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0 - 0.5

C57BL/6JfC3Hf/Nctr Thyroid gland adenoma Thyroid gland

observed

BALB/cStCrlfC3Hf/Nctr Thyroid gland adenoma Thyroid gland

observed

BALB/cStCrlfC3Hf/Nctr Urinary bladder tumor Urinary bladder

0

C57BL/6JfC3Hf/Nctr Urinary bladder tumor Urinary bladder

0

BALB/cStCrlfC3Hf/Nctr Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

0 - 3.7

C57BL/6JfC3Hf/Nctr Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

0 - 30

BALB/cStCrlfC3Hf/Nctr Uterus adenocarcinoma Uterus

observed

BALB/cStCrlfC3Hf/Nctr Uterus polyp Uterus

0 - 36

C57BL/6JfC3Hf/Nctr Uterus polyp Uterus

0 - 1.0

BALB/cStCrlfC3Hf/Nctr Vagina dysplasia Vagina

0 - 11

C57BL/6JfC3Hf/Nctr Vagina dysplasia Vagina

0 - 1.0

BALB/cStCrlfC3Hf/Nctr (Unspecified organ) angioma (Unspecified organ)

0 - 2.7

C57BL/6JfC3Hf/Nctr (Unspecified organ) angiosarcoma (Unspecified organ)

0 - 14

BALB/cStCrlfC3Hf/Nctr (Unspecified organ) angiosarcoma (Unspecified organ)

0 - 6.3