Reference SummaryCosgrove GE, J Gerontol 1978 Mar;33(2):178-83

Title

 Diseases of aging untreated virgin female RFM and BALB/c mice.

Authors

 Cosgrove GE; Satterfield LC; Bowles ND; Klima WC

Journal

 J Gerontol

Volume

 33

Issue

 2

Year

 1978

Pages

 178-83

Abstract

 Diseases of untreated, virgin female barrier-maintained RFM and BALB/c mice used as controls in a large radiation aging experiment were necropsied after natural death. The spectrum and incidence of neoplastic and nonneoplastic diseases were somewhat different in the two strains. Both strains show a high incidence of neoplasma (largely reticulum cell sarcomas and lung tumors) and of glomerulosclerosis. A wide variety of other diseases was noted in much lower incidence. The findings in the RF were briefly compared with those in earlier experiments with that strain in this laboratory.

Links

 J:27633 – MGI References
342593 – National Library of Medicine/PubMed

Strain Notes

Strain Note
BALB/cAnNBdf These mice were "germfree-derived" and were housed under "specific-pathogen-free" conditions.
RFM/Un These mice were "germfree-derived" and were housed under "specific-pathogen-free" conditions.
RF/Un These mice were described as "random-bred".

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
RFM/Un Adrenal gland - Cortex hyperplasia Adrenal gland - Cortex

2
BALB/cAnNBdf Adrenal gland - Cortex hyperplasia Adrenal gland - Cortex

40
RFM/Un Adrenal gland - Cortex tumor Adrenal gland - Cortex

1
BALB/cAnNBdf Adrenal gland - Cortex tumor Adrenal gland - Cortex

29
RFM/Un Blood hyperplasia Blood

33
BALB/cAnNBdf Blood hyperplasia Blood

37
RFM/Un Blood vessel tumor Blood vessel

1
BALB/cAnNBdf Blood vessel tumor Blood vessel

5
RFM/Un Eye - Harderian gland tumor Eye - Harderian gland

3
BALB/cAnNBdf Eye - Harderian gland tumor Eye - Harderian gland

11
RF/Un Eye - Harderian gland tumor Eye - Harderian gland

0 - very low
RFM/Un Gastrointestinal tract tumor Gastrointestinal tract

1
BALB/cAnNBdf Gastrointestinal tract tumor Gastrointestinal tract

4
RFM/Un Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
BALB/cAnNBdf Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

1
RF/Un Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0 - 3
RFM/Un Leukocyte lymphoma Thymus

8
BALB/cAnNBdf Leukocyte lymphoma Thymus

1
RF/Un Leukocyte lymphoma Thymus

3 - 15
RFM/Un Leukocyte lymphoma - blast cell Leukocyte

observed
BALB/cAnNBdf Leukocyte lymphoma - blast cell Leukocyte

observed
RFM/Un Leukocyte lymphoma - lymphosarcoma Leukocyte

observed
BALB/cAnNBdf Leukocyte lymphoma - lymphosarcoma Leukocyte

observed
RFM/Un Leukocyte neoplasm Leukocyte

78
BALB/cAnNBdf Leukocyte neoplasm Leukocyte

67
RF/Un Leukocyte neoplasm Leukocyte

37 - 68
RFM/Un Lung adenoma Lung

observed
BALB/cAnNBdf Lung adenoma Lung

observed
RFM/Un Lung carcinoma Lung

observed
BALB/cAnNBdf Lung carcinoma Lung

observed
RFM/Un Lung tumor Lung

26
BALB/cAnNBdf Lung tumor Lung

32
RF/Un Lung tumor Lung

17 - 37
RFM/Un Mammary gland carcinoma Mammary gland

0
BALB/cAnNBdf Mammary gland carcinoma Mammary gland

13
RFM/Un Mammary gland hyperplasia Mammary gland

39
BALB/cAnNBdf Mammary gland hyperplasia Mammary gland

27
RF/Un Mammary gland tumor Mammary gland

1 - very low
RFM/Un Myoepithelial cell myoepithelioma Myoepithelial cell

0
BALB/cAnNBdf Myoepithelial cell myoepithelioma Myoepithelial cell

3
RFM/Un Ovary cyst Ovary

9
BALB/cAnNBdf Ovary cyst Ovary

8
RFM/Un Ovary tumor Ovary

1
BALB/cAnNBdf Ovary tumor Ovary

8
RF/Un Ovary tumor Ovary

3 - 15
RFM/Un Pituitary gland adenoma Pituitary gland

7
BALB/cAnNBdf Pituitary gland adenoma Pituitary gland

0
RFM/Un Pituitary gland tumor Pituitary gland

1 - 7
BALB/cAnNBdf Pituitary gland tumor Pituitary gland

8
RF/Un Pituitary gland tumor Pituitary gland

0 - very low
RFM/Un Uterus hyperplasia Uterus

87
BALB/cAnNBdf Uterus hyperplasia Uterus

62
RFM/Un Uterus tumor Uterus

3
BALB/cAnNBdf Uterus tumor Uterus

3
RFM/Un (Unspecified organ) neoplasm (Unspecified organ)

88
BALB/cAnNBdf (Unspecified organ) neoplasm (Unspecified organ)

94
RFM/Un (Unspecified organ) reticulum cell sarcoma (Unspecified organ)

67
BALB/cAnNBdf (Unspecified organ) reticulum cell sarcoma (Unspecified organ)

61
RF/Un (Unspecified organ) reticulum cell sarcoma (Unspecified organ)

22 - 56
RF/Un (Unspecified organ) tumor (Unspecified organ)

66 - 72
RFM/Un (Unspecified organ) tumor - unclassified (Unspecified organ)

3
BALB/cAnNBdf (Unspecified organ) tumor - unclassified (Unspecified organ)

4