Reference SummaryDixon D, Exp Lung Res 1991 Mar-Apr;17(2):131-55

Title

Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice.

Authors

Dixon D; Horton J; Haseman JK; Talley F; Greenwell A; Nettesheim P; Hook GE; Maronpot RR

Journal

Exp Lung Res

Volume

17

Issue

2

Year

1991

Pages

131-55

Abstract

The microscopic and ultrastructural characteristics of spontaneous pulmonary neoplasms in strain A (strA) mice are described. Fifty-one spontaneous lung tumors were identified in 34 out of 57, 11-23-month-old male strA/Hen mice. Grossly, all tumors appeared as yellow-white, discrete nodules ranging in size from 1.0-10 mm. Tumor types were randomly distributed throughout the lung; however, the right lung lobes were most frequently involved. Histologically, tumors were classified as adenoma (34/51) or carcinoma (17/51) as defined by standard histopathologic criteria. Adenomas were usually less than 4 mm in diameter and had solid (16/34), papillary (10/34), or mixed (8/34) histologic growth patterns. Carcinomas were usually greater than 4 mm in diameter and had papillary (13/17) or mixed (4/17) histologic growth patterns. Ultrastructurally, benign tumors consisted of solid or papillary areas of neoplastic type II-like cells. Cells comprising malignant tumors had varying ultrastructural characteristics ranging from well-differentiated alveolar cell types to undifferentiated cells having intracytoplasmic osmiophilic dense bodies, vacuoles, or few specialized organelles commonly observed in mature nonneoplastic pulmonary epithelial cells.

Links

J:27691 – MGI References
1646706 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
A/HeN Lung - Club cell hyperplasia Lung - Club cell

observed

A/HeN Lung adenoma - mixed Lung

observed

A/HeN Lung adenoma - papillary Lung

observed

A/HeN Lung adenoma - solid Lung

observed

A/HeN Lung carcinoma - mixed Lung

observed

A/HeN Lung carcinoma - papillary Lung

observed

A/HeN Lung carcinoma - solid Lung

0

A/HeN Lung tumor Lung

33 - 86