Reference SummaryWhitmire CE, J Natl Cancer Inst 1979 Mar;62(3):555-9

Title

 Effects of subcutaneous administration of chemical carcinogens on leukemia in C58 mice.

Authors

 Whitmire CE

Journal

 J Natl Cancer Inst

Volume

 62

Issue

 3

Year

 1979

Pages

 555-9

Abstract

 The effects of sc administration of 3-methylcholanthrene (MCA), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (BP) on spontaneous viral leukemia and subcutaneous sarcoma induction have been studied in weanling C58/J mice. MCA produced significantly more sarcomas at the inoculation site than did DMBA or BP; moreover, it interfered with leukemia development. DMBA produced fewer sarcomas, and the incidence of leukemia was comparable to that found in the controls. BP accelerated the incidence of leukemia, although no sarcomas were produced. When the effect of the age of the mice at the time of MCA treatment on the incidence of leukemia and sarcomas was studied, newborn and weanling mice were found to develop primarily sarcomas, whereas no sarcomas were produced in the 16-week-old mice, and 52-64% of the 16-week-old mice developed leukemia. The reason no sarcomas were found in the C58 mice was apparently different from the reason no sarcomas were found in AKR mice, inasmuch as the AKR mice did not live long enough for sarcomas to develop. Immunologic surveillance may have played a part in the sarcoma suppression in the C58 mouse.

Links

 J:32292 – MGI References
216841 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C58/LwN Leukocyte leukemia Leukocyte

32
C58/LwN Leukocyte leukemia
  • 3-methylcholanthrene (MCA) (3-MC)
 Leukocyte

0 - 5
C58/LwN Leukocyte leukemia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
 Leukocyte

22 - 35
C58/LwN Leukocyte leukemia
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Leukocyte

52
C58/J Leukocyte leukemia Leukocyte

13 - 52
C58/J Leukocyte leukemia
  • 3-methylcholanthrene (MCA) (3-MC)
 Leukocyte

0 - 64
C58/J Mesodermal cell/mesoblast sarcoma
  • 3-methylcholanthrene (MCA) (3-MC)
 Mesodermal cell/mesoblast

0 - 100
C58/LwN Mesodermal cell/mesoblast sarcoma
  • 3-methylcholanthrene (MCA) (3-MC)
 Mesodermal cell/mesoblast

83 - 95
C58/LwN Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

0
C58/LwN Mesodermal cell/mesoblast sarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
 Mesodermal cell/mesoblast

20 - 48
C58/LwN Mesodermal cell/mesoblast sarcoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Mesodermal cell/mesoblast

0
C58/J Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

0