Reference SummaryBradlow HL, Proc Natl Acad Sci U S A 1985 Sep;82(18):6295-9

Title

 Estradiol 16 alpha-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans.

Authors

 Bradlow HL; Hershcopf RJ; Martucci CP; Fishman J

Journal

 Proc Natl Acad Sci U S A

Volume

 82

Issue

 18

Year

 1985

Pages

 6295-9

Abstract

 In this report, we describe our findings on the relationship between estradiol 16 alpha-hydroxylation and mammary tumor incidence. A close correlation between the two has been demonstrated with 16-hydroxylation being elevated in strains with a high incidence of tumors, such as RIII and C3H, and low in strains with a low incidence of cancer, such as C57BL. The extent of reaction is highly reproducible and unaffected by age or presence of overt mammary tumors. Studies on the inheritance of estradiol 16 alpha-hydroxylase showed that it is inherited as an autosomal dominant and is not correlated with estradiol 2-hydroxylase or androgen and progestin 16 alpha-hydroxylases. In addition, the reaction was shown to be markedly enhanced by the presence of murine mammary tumor virus and diminished in the absence of the virus. These studies establish a relationship between genetics, hormonal factors, and murine mammary tumor virus, the three key factors in mammary tumorigenesis.

Links

 J:37506 – MGI References
2994069 – National Library of Medicine/PubMed

Strain Notes

Strain Note
129 Mice were NOT carriers of infectious MMTV.
129fC3H/HeOuJ Mice were carriers of infectious MMTV.
BALB/cBy Mice were NOT carriers of infectious MMTV.
BALB/cfC3H/HeOuJ Mice were carriers of infectious MMTV.
C3H/HeJ Mice were carriers of infectious MMTV.
C3H/HeOuJ Mice were carriers of infectious MMTV.
C57BL/6J Mice were NOT carriers of infectious MMTV.
C57BR/cdJ Mice were NOT carriers of infectious MMTV.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/cBy Mammary gland tumor Mammary gland

10.0 - 20.0
C3H/HeJ Mammary gland tumor
  • MMTV - mouse mammary tumor virus
 Mammary gland

100
C3H/HeOuJ Mammary gland tumor
  • MMTV - mouse mammary tumor virus
 Mammary gland

100
C57BL/6J Mammary gland tumor Mammary gland

1
C57BR/cdJ Mammary gland tumor Mammary gland

0
C57L/J Mammary gland tumor Mammary gland

1
CBA/J Mammary gland tumor Mammary gland

40
DBA/J Mammary gland tumor Mammary gland

30
RIII Mammary gland tumor Mammary gland

100
BALB/cfC3H/HeOuJ Mammary gland tumor
  • MMTV - mouse mammary tumor virus
 Mammary gland

high
129 Mammary gland tumor
  • MMTV - mouse mammary tumor virus
 Mammary gland

0
129fC3H/HeOuJ Mammary gland tumor
  • MMTV - mouse mammary tumor virus
 Mammary gland

0