Reference SummaryMahler JF, Toxicol Pathol 1996 Nov-Dec;24(6):710-6

Title

Spontaneous lesions in aging FVB/N mice.

Authors

Mahler JF; Stokes W; Mann PC; Takaoka M; Maronpot RR

Journal

Toxicol Pathol

Volume

24

Issue

6

Year

1996

Pages

710-6

Abstract

The FVB/N mouse strain was created in the early 1970s and has since been used extensively in transgenic research because of its well-defined inbred background, superior reproductive performance, and prominent pronuclei of fertilized zygotes, which facilitate microinjection of DNA. Little is known, however, about the survivability and spontaneous disease of nontransgenic FVB/N mice. Therefore, the purpose of this study was to determine survival to 24 mo of age and the incidence of neoplastic and nonneoplastic disease at 14 and 24 mo of age. At 14 mo of age, the incidence of tumor-bearing mice was 13% in males (n = 45) and 26% in females (n = 98). All tumors in males and most in females at this time were alveolar-bronchiolar (AB) neoplasms of the lung. Survival to 24 mo of age was approximately 60% in both sexes (29/50 males, 71/116 females), and the incidence of mice with tumors at this time was 55% in males and 66% in females. In decreasing order of frequency, the following neoplasms were observed in > 5% of subjects: in males, lung AB tumors, liver hepatocellular tumors, subcutis neural crest tumors, and Harderian gland adenomas; in females, lung AB tumors, pituitary gland adenomas, ovarian tumors (combined types), lymphomas, histiocytic sarcomas, Harderian gland adenomas, and pheochromocytomas. Compared with other mouse strains, the observed incidences of tumors in FVB/N mice suggest a higher than usual rate of lung tumors and a lower than usual incidence of liver tumors and lymphomas. This tumor profile should be considered in the interpretation of neoplastic phenotypes in FVB/N-derived transgenic lines.

Links

J:38438 – Mouse Genome Informatics
8994298 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/NHsd Adipose tissue liposarcoma Subcutis

0

FVB/NTac Adipose tissue liposarcoma Subcutis

0 - 1.4

(C57BL/6 x C3H)F1 Adrenal gland - Cortex tumor Adrenal gland - Cortex

4

FVB/NTac Adrenal gland - Cortex tumor Adrenal gland - Cortex

0

FVB/NHsd Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0

FVB/NTac Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

3.6 - 6

(C57BL/6 x C3H)F1 Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

2

FVB/NHsd Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Subcapsular cell

0 - 29

FVB/NTac Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Subcapsular cell

14 - 83

FVB/NHsd Blood vessel hemangioma Blood vessel

0

FVB/NTac Blood vessel hemangioma Blood vessel

0

FVB/NTac Blood vessel hemangioma Ovary

1.4

FVB/NTac Blood vessel hemangioma Spleen

1.4

(C57BL/6 x C3H)F1 Blood vessel tumor Blood vessel

6

FVB/NHsd CNS - Brain - Undifferentiated cell tumor Skin

0 - 1.0

FVB/NTac CNS - Brain - Undifferentiated cell tumor Skin

2.8 - 6.9

FVB/NTac CNS - Brain - Undifferentiated cell tumor Preputial gland (male)

3.4

FVB/NHsd Connective tissue - Fibroblast fibroma Uterus

1.0

FVB/NTac Connective tissue - Fibroblast fibroma Uterus

0

FVB/NHsd Eye - Harderian gland adenoma Eye - Harderian gland

0

FVB/NTac Eye - Harderian gland adenoma Eye - Harderian gland

5.6 - 6.9

FVB/NTac Eye - Harderian gland tumor Eye - Harderian gland

6 - 7

(C57BL/6 x C3H)F1 Eye - Harderian gland tumor Eye - Harderian gland

4 - 5

FVB/NHsd Gallbladder papilloma Gallbladder

0

FVB/NTac Gallbladder papilloma Gallbladder

0 - 1.4

FVB/NTac Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

5.6 - 6

FVB/NHsd Leukocyte - Lymphocyte hyperplasia Spleen - White pulp

0

FVB/NTac Leukocyte - Lymphocyte hyperplasia Spleen - White pulp

0 - 11

FVB/NHsd Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 1.0

FVB/NTac Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 6

C57BL/6 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

10 - 22

(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0.3 - 1

FVB/NHsd Leukocyte lymphoma Leukocyte

0

FVB/NTac Leukocyte lymphoma Leukocyte

0

(C57BL/6 x C3H)F1 Leukocyte lymphoma Leukocyte

9 - 25

FVB/NHsd Liver hepatocellular adenoma Liver

0

FVB/NTac Liver hepatocellular adenoma Liver

0 - 17

FVB/NHsd Liver hepatocellular carcinoma Liver

0

FVB/NTac Liver hepatocellular carcinoma Liver

0 - 14

FVB/NTac Liver tumor Liver

0 - 21.0

(C57BL/6 x C3H)F1 Liver tumor Liver

17 - 36

C57BL Liver tumor Liver

5

C3H Liver tumor Liver

80

FVB/NHsd Lung - Alveolus hyperplasia Lung - Alveolus

1.0 - 4.4

FVB/NTac Lung - Alveolus hyperplasia Lung - Alveolus

6.9 - 11

FVB/NHsd Lung adenoma Lung

6.7 - 9.2

FVB/NTac Lung adenoma Lung

18 - 28

FVB/NHsd Lung carcinoma Lung

5.1 - 6.7

FVB/NTac Lung carcinoma Lung

21 - 28

FVB/NTac Lung tumor Lung

37 - 41

(C57BL/6 x C3H)F1 Lung tumor Lung

7 - 18

A Lung tumor Lung

100

C57BL Lung tumor Lung

3

FVB/NHsd Muscle - Smooth leiomyoma Uterus

1.0

FVB/NTac Muscle - Smooth leiomyoma Uterus

0

FVB/NHsd Muscle - Smooth leiomyosarcoma Uterus

0

FVB/NTac Muscle - Smooth leiomyosarcoma Uterus

1.4

FVB/NHsd Ovary - Germ cell teratoma Ovary - Germ cell

2.0

FVB/NTac Ovary - Germ cell teratoma Ovary - Germ cell

1.4

FVB/NHsd Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

FVB/NTac Ovary - Granulosa cell tumor Ovary - Granulosa cell

2.8

FVB/NHsd Ovary - Sertoli cell tumor Ovary - Sertoli cell

0

FVB/NTac Ovary - Sertoli cell tumor Ovary - Sertoli cell

1.4

FVB/NHsd Ovary cystadenoma Ovary

0

FVB/NTac Ovary cystadenoma Ovary

1.4

FVB/NTac Ovary tumor Ovary

7

FVB/NHsd Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0

FVB/NTac Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0 - 3.4

FVB/NHsd Pituitary gland - Pars distalis adenoma Pituitary gland - Pars distalis

0 - 5.5

FVB/NTac Pituitary gland - Pars distalis adenoma Pituitary gland - Pars distalis

0 - 14

FVB/NHsd Pituitary gland - Pars distalis hyperplasia Pituitary gland - Pars distalis

0 - 3.3

FVB/NTac Pituitary gland - Pars distalis hyperplasia Pituitary gland - Pars distalis

0 - 7.2

FVB/NTac Pituitary gland - Pars distalis tumor Pituitary gland - Pars distalis

15

(C57BL/6 x C3H)F1 Pituitary gland - Pars distalis tumor Pituitary gland - Pars distalis

16

FVB/NHsd Placenta - Trophoblast choriocarcinoma Uterus

1.0

FVB/NTac Placenta - Trophoblast choriocarcinoma Uterus

0

FVB/NHsd Skin - Epidermis squamous cell papilloma Skin - Epidermis

0

FVB/NTac Skin - Epidermis squamous cell papilloma Skin - Epidermis

0 - 1.4

FVB/NHsd Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

0

FVB/NTac Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

3.4

FVB/NHsd Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

2.2

FVB/NTac Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

3.4

FVB/NHsd Thyroid gland tumor Thyroid gland

0

FVB/NTac Thyroid gland tumor Thyroid gland

0