Reference SummaryYang K, J Exp Zool 1997 Feb 15;277(3):245-54
Title |
A mouse model of human familial adenomatous polyposis. |
Authors |
Yang K; Edelmann W; Fan K; Lau K; Kolli VR; Fodde R; Khan PM; Kucherlapati R; Lipkin M |
Journal |
J Exp Zool |
Volume |
277 |
Issue |
3 |
Year |
1997 |
Pages |
245-54 |
Abstract |
In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they included adenomas, adenocarcinomas, and polypoid hyperplasias. The mice developed an average of 3.3 tumors, with the highest number in duodenum, followed by jejunum, stomach, ileum, and colon. Focal areas of dysplasias were observed in the colonic mucosa in 50% of mice which were 10 months old or older. These results suggest that mice carrying the Apc1638 mutation can serve as a good model to study the initiation, progression, and inhibition of gastrointestinal tumors. (C) 1997 Wiley-Liss, Inc. |
Links |
J:38850 – MGI References 9062998 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J | Gastrointestinal tract tumor | Gastrointestinal tract |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Gastrointestinal tract tumor | Gastrointestinal tract |
62.5 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon - Distal adenocarcinoma | Intestine - Large Intestine - Colon - Distal |
0 |
||
| C57BL/6J | Intestine - Large Intestine - Colon - Distal adenocarcinoma | Intestine - Large Intestine - Colon - Distal |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon - Distal adenoma | Intestine - Large Intestine - Colon - Distal |
4.2 |
||
| C57BL/6J | Intestine - Large Intestine - Colon - Distal adenoma | Intestine - Large Intestine - Colon - Distal |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon - Medial adenocarcinoma | Intestine - Large Intestine - Colon - Medial |
0 |
||
| C57BL/6J | Intestine - Large Intestine - Colon - Medial adenocarcinoma | Intestine - Large Intestine - Colon - Medial |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon - Medial adenoma | Intestine - Large Intestine - Colon - Medial |
0 |
||
| C57BL/6J | Intestine - Large Intestine - Colon - Medial adenoma | Intestine - Large Intestine - Colon - Medial |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon - Proximal adenocarcinoma | Intestine - Large Intestine - Colon - Proximal |
0 |
||
| C57BL/6J | Intestine - Large Intestine - Colon - Proximal adenocarcinoma | Intestine - Large Intestine - Colon - Proximal |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon - Proximal adenoma | Intestine - Large Intestine - Colon - Proximal |
4.2 |
||
| C57BL/6J | Intestine - Large Intestine - Colon - Proximal adenoma | Intestine - Large Intestine - Colon - Proximal |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon dysplasia | Intestine - Large Intestine - Colon |
17 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon |
observed |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
8.3 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Duodenum adenocarcinoma | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6J | Intestine - Small Intestine - Duodenum adenocarcinoma | Intestine - Small Intestine - Duodenum |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6J | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Duodenum dysplasia | Intestine - Small Intestine - Duodenum |
17 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum |
42 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Ileum adenocarcinoma | Intestine - Small Intestine - Ileum |
12.5 |
||
| C57BL/6J | Intestine - Small Intestine - Ileum adenocarcinoma | Intestine - Small Intestine - Ileum |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
4.2 |
||
| C57BL/6J | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Ileum tumor | Intestine - Small Intestine - Ileum |
17 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Jejunum adenocarcinoma | Intestine - Small Intestine - Jejunum |
observed |
||
| C57BL/6J | Intestine - Small Intestine - Jejunum adenocarcinoma | Intestine - Small Intestine - Jejunum |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |
||
| C57BL/6J | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine - Small Intestine - Jejunum tumor | Intestine - Small Intestine - Jejunum |
37.5 |
||
| B6129P2F1-Apctm1Rak/+ | Intestine dysplasia | Intestine |
50 |
||
| B6129P2F1-Apctm1Rak/+ | Stomach adenocarcinoma | Stomach |
observed |
||
| C57BL/6J | Stomach adenocarcinoma | Stomach |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Stomach adenoma | Stomach |
observed |
||
| C57BL/6J | Stomach adenoma | Stomach |
0 |
||
| B6129P2F1-Apctm1Rak/+ | Stomach dysplasia | Stomach |
17 |
||
| B6129P2F1-Apctm1Rak/+ | Stomach tumor | Stomach |
25 |