Reference SummaryGroch KM, Int J Radiat Biol 1997 Mar;71(3):301-8

Title

Lung cancer response following inhaled radon in the A/J and C57BL/6J mouse.

Authors

Groch KM; Khan MA; Brooks AL; Saffer JD

Journal

Int J Radiat Biol

Volume

Issue

Year

1997

Pages

301-8

Abstract

A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C57BL/6J mice. In contrast, each of the A/J groups had a substantial number of tumours. Although there were no differences in overall lung tumour incidence or multiplicity associated with radon and ore dust exposure in A/J mice, distinct differences in tumour size and histopathological appearance were noted. The ratio of lung adenoma-to-carcinoma found in control A/J mice was 10:1, whereas the ratio in one dust-exposed animals was 10:8 and that in radon-exposed animals was 8:6. Based on these data, particulates appear to modify the promotion-progression of lung cancer in this strain. In addition, the appearance of two very large carcinomas histologically resembling Clara-cell-derived tumours only in the radon-exposed A/J mice and the possibility of alpha-particle-induced killing of target cells in the radon-exposed animals suggests that A/J but not the C57BL/6J, mice may have genes that modify susceptibility to radon-induced lung cancer.

Links

J:39931 – MGI References
9134020 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
A/J	These mice were from the Jackson Laboratory.
C57BL/6J	These mice were from the Jackson Laboratory.

Models
Strain	Model Name	Treatment Agent(s)	Organ Affected	Frequency
A/J	Lung - Club cell carcinoma	radon	Lung - Club cell	11
A/J	Lung adenoma		Lung	observed
A/J	Lung adenoma	uranium ore dust	Lung	observed
A/J	Lung adenoma	radon	Lung	observed
A/J	Lung carcinoma		Lung	observed
A/J	Lung carcinoma	uranium ore dust	Lung	observed
A/J	Lung carcinoma	radon	Lung	observed
A/J	Lung hyperplasia	radon	Lung	observed - 10
A/J	Lung hyperplasia		Lung	observed
A/J	Lung hyperplasia	uranium ore dust	Lung	observed
A/J	Lung tumor	uranium ore dust	Lung	0 - 60
A/J	Lung tumor	radon	Lung	10 - 72
A/J	Lung tumor	urethane (ethyl carbamate)	Lung	100
C57BL/6J	Lung tumor	uranium ore dust	Lung	0
C57BL/6J	Lung tumor	radon	Lung	0
C57BL/6J	Lung tumor	urethane (ethyl carbamate)	Lung	60
A/J	Lung tumor		Lung	64
C57BL/6J	Lung tumor		Lung	0