Reference SummaryMarsella JM, Environ Health Perspect 1997 Sep;105 Suppl 5():1069-72

Title

 Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.

Authors

 Marsella JM; Liu BL; Vaslet CA; Kane AB

Journal

 Environ Health Perspect

Volume

 105 Suppl 5

Issue

Year

 1997

Pages

 1069-72

Abstract

 Exposure of mesothelial cells to asbestos fibers in vitro has been shown to induce DNA damage mediated by oxidants. An early cellular response to DNA damage is increased expression of the p53 protein. This protein induces transcription of genes that activate cell cycle checkpoints or induce apoptosis. A murine mesothelial cell line that spontaneously acquired a point mutation in the p53 gene shows increased sensitivity to DNA damage induced by crocidolite asbestos fibers. It is hypothesized that p53-deficient mice will show increased sensitivity to the genotoxic effects of asbestos and accelerated development of malignant mesotheliomas.

Links

 9400702 – National Library of Medicine/PubMed
J:44660 – MGI References

Strain Notes

Strain Note
129-Trp53tm1Tyj/J These mice were from The Jackson Laboratory.
129-Trp53tm1Tyj/J These mice were from The Jackson Laboratory.
129S1/SvImJ These mice were purchased from the Jackson Laboratory.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
129-Trp53tm1Tyj/J Blood vessel hemangiosarcoma
  • crocidolite asbestos
 Blood vessel

observed
129-Trp53tm1Tyj/J Blood vessel hemangiosarcoma Blood vessel

observed
129-Trp53tm1Tyj/J Leukocyte lymphoma
  • crocidolite asbestos
 Thymus

observed
129-Trp53tm1Tyj/J Leukocyte lymphoma Thymus

observed
129-Trp53tm1Tyj/J Mesothelium mesothelioma - malignant
  • crocidolite asbestos
 Mesothelium

12.5
129-Trp53tm1Tyj/J Mesothelium mesothelioma - malignant
  • crocidolite asbestos
 Mesothelium

76
129S1/SvImJ Mesothelium mesothelioma - malignant
  • crocidolite asbestos
 Mesothelium

32
129-Trp53tm1Tyj/J Mesothelium mesothelioma - malignant Mesothelium

0
129-Trp53tm1Tyj/J Mesothelium mesothelioma - malignant Mesothelium

0
129S1/SvImJ Mesothelium mesothelioma - malignant Mesothelium

0