Reference SummarySheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Title

 Primary harderian gland neoplasms in mice.

Authors

 Sheldon WG; Curtis M; Kodell RL; Weed L

Journal

 J Natl Cancer Inst

Volume

 71

Issue

 1

Year

 1983

Pages

 61-8

Abstract

 Five hundred and seventy-four spontaneous harderian gland neoplasms were observed in 3,123 male and 9,024 female untreated experimental mice of various ages and of 6 inbred strains and substrains and 3 hybrid stocks. Adenomas occurred in 86 males and 458 females, and adenocarcinomas were present in 3 males and 27 females. The highest tumor incidence occurred in mice after 24 months of age; no tumors were observed in any mice prior to 6 months of age. With the exception of 1 age group, both sexes of the BALB/c mice had the highest incidence, and also this strain accounted for 463 of the neoplasms. The adenomas were classified into one of four different histologic types: papillary, cystic papillary, acinar, and cystic. The papillary type was the most frequently observed in both sexes. The cystic papillary type was the second most frequently observed and was the type most frequently associated with gross lesions. This type may represent a developmental variant of the papillary type. The incidence of the acinar type was similar in both sexes. The cystic type had the lowest incidence. All except 3 adenocarcinomas appeared to evolve from adenomas, with evolvement occurring primarily in the acinar type. Five of the adenocarcinomas either metastasized to the lung or invaded periorbital tissues. The remaining 25 were confined to the harderian gland.

Links

 J:48633 – MGI References
6575211 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0.2 - 0.4
C57BL/6JfC3Hf/Nctr Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0 - 0.1
C3H/HeNNctr-MTV- Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0.4
C3H/HeJ Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0.3
C3HeB/FeJ Eye - Harderian gland adenocarcinoma Eye - Harderian gland

1.0
BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland adenoma - acinar Eye - Harderian gland

0.5 - 0.8
C57BL/6JfC3Hf/Nctr Eye - Harderian gland adenoma - acinar Eye - Harderian gland

0.3 - 0.4
C3H/HeNNctr-MTV+ Eye - Harderian gland adenoma - acinar
  • MMTV - mouse mammary tumor virus
 Eye - Harderian gland

0.6
C3H/HeNNctr-MTV- Eye - Harderian gland adenoma - acinar Eye - Harderian gland

1.1
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Eye - Harderian gland adenoma - acinar Eye - Harderian gland

0.3
C3H/HeJ Eye - Harderian gland adenoma - acinar Eye - Harderian gland

1.4
C3HeB/FeJ Eye - Harderian gland adenoma - acinar Eye - Harderian gland

0.5
BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0 - 0.2
C57BL/6JfC3Hf/Nctr Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.1
C3H/HeNNctr-MTV- Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.4
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.3
C3H/HeJ Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.3
C3HeB/FeJ Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.5
(C3H x VY Avy/a?)F1 Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.2
BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

0.5 - 2.3
C57BL/6JfC3Hf/Nctr Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

0.3
C3H/HeNNctr-MTV- Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

0.4
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

0.6 - 1.6
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

1.2 - 1.6
C3H/HeJ Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

0.3
C3HeB/FeJ Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

1.0
BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland adenoma - papillary Eye - Harderian gland

2.7 - 4.7
C57BL/6JfC3Hf/Nctr Eye - Harderian gland adenoma - papillary Eye - Harderian gland

0.4 - 0.6
C3H/HeNNctr-MTV- Eye - Harderian gland adenoma - papillary Eye - Harderian gland

1.1
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Eye - Harderian gland adenoma - papillary Eye - Harderian gland

1.2 - 1.6
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Eye - Harderian gland adenoma - papillary Eye - Harderian gland

0.3 - 2.7
C3H/HeJ Eye - Harderian gland adenoma - papillary Eye - Harderian gland

1.4
C3HeB/FeJ Eye - Harderian gland adenoma - papillary Eye - Harderian gland

2.0
(C3H x VY Avy/a?)F1 Eye - Harderian gland adenoma - papillary Eye - Harderian gland

0.2
BALB/cStCrlfC3Hf/Nctr Eye - Harderian gland tumor Eye - Harderian gland

3.9 - 8.5
C57BL/6JfC3Hf/Nctr Eye - Harderian gland tumor Eye - Harderian gland

1.1 - 1.3
C3H/HeNNctr-MTV+ Eye - Harderian gland tumor
  • MMTV - mouse mammary tumor virus
 Eye - Harderian gland

0.6
C3H/HeNNctr-MTV- Eye - Harderian gland tumor Eye - Harderian gland

3.3
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Eye - Harderian gland tumor Eye - Harderian gland

1.8 - 3.2
(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Eye - Harderian gland tumor Eye - Harderian gland

2.6 - 4.2
C3H/HeJ Eye - Harderian gland tumor Eye - Harderian gland

3.8
C3HeB/FeJ Eye - Harderian gland tumor Eye - Harderian gland

5.1
(C3H x VY Avy/a?)F1 Eye - Harderian gland tumor Eye - Harderian gland

0.4