Reference SummaryBruckheimer EM, Oncogene 2000 Nov 2;19(46):5251-8
Title |
Bcl-2 accelerates multistep prostate carcinogenesis in vivo | ||||
Authors |
Bruckheimer EM; Brisbay S; Johnson DJ; Gingrich JR; Greenberg N; McDonnell TJ | ||||
Journal |
Oncogene | ||||
Volume |
19 | ||||
Issue |
46 | ||||
Year |
2000 | ||||
Pages |
5251-8 | ||||
Abstract |
The impact of bcl-2 proto-oncogene expression on the pathogenesis and progression of prostate cancer was examined in a transgenic mouse model. Probasin-bcl-2 transgenic mice were crossed with TRAMP (TRansgenic Adenocarcinoma Mouse Prostate) mice that express the SV40 early genes (T/t antigens) under probasin control. Prostate size, cell proliferation, apoptosis, and the incidence and latency of tumor formation were evaluated. The double transgenic, probasin-bcl-2 X TRAMP F1 (BxT) mice exhibited an increase in the wet weight of the prostate. This was associated with an increase in proliferation, attributable to T/t antigens, and a decrease in apoptosis attributable to bcl-2. The latency to tumor formation was also decreased in the BxT mice compared to the TRAMP mice. The incidence of metastases was identical in both the TRAMP and BxT mice. Lastly, the incidence of hormone-independent prostate cancer was reduced in the BxT mice compared to the TRAMP mice. Together, these results demonstrate that bcl-2 can facilitate multistep prostate carcinogenesis in vivo. Oncogene (2000) 19, 5251 - 5258. | ||||
Links |
J:65876 – MGI References 11077442 – National Library of Medicine/PubMed |
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Strain Notes
|
|||||
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6-Tg(BCL2)#Tjd Tg(TRAMP)8247Ng | Prostate gland carcinoma | Prostate gland |
20 - 100 |
||
| C57BL/6-Tg(TRAMP)8247Ng | Prostate gland carcinoma | Prostate gland |
16 - 100 |
||
| C57BL/6-Tg(BCL2)#Tjd Tg(TRAMP)8247Ng | Prostate gland tumor |
|
Prostate gland |
11 |
|
| B6.FVB-Tg(BCL2)#Tjd | Prostate gland tumor |
|
Prostate gland |
0 |
|
| C57BL/6-Tg(TRAMP)8247Ng | Prostate gland tumor |
|
Prostate gland |
36 |
|
| C57BL/6 | Prostate gland tumor |
|
Prostate gland |
0 |