Reference SummaryYou M, Proc Natl Acad Sci U S A 1992 Jul 1;89(13):5804-8

Title

Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.

Authors

You M; Wang Y; Stoner G; You L; Maronpot R; Reynolds SH; Anderson M

Journal

Proc Natl Acad Sci U S A

Volume

89

Issue

13

Year

1992

Pages

5804-8

Abstract

A mouse strain with low lung tumor susceptibility (C3H) and a strain with high lung tumor susceptibility (A/J) were reciprocally crossed to produce C3A and AC3 F1 hybrid mice. Ki-ras oncogenes were detected in spontaneous and chemically induced lung tumors obtained from the C3A and AC3 mice. To further explore the genetics of the Ki-ras gene in mouse lung tumor susceptibility, the parental origin of Ki-ras oncogenes detected in lung tumors from the F1 hybrids was determined by a strategy based on a 37-base-pair deletion in the second intron of the A/J Ki-ras allele. Ki-ras oncogenes were derived from the A/J parent in 38 of 40 tumors obtained from C3A mice and 30 of 30 tumors from AC3 mice. The observation that the activated oncogene in hybrids originates from the susceptible parent suggests that the Ki-ras gene is directly linked to mouse lung tumor susceptibility. This finding may have implications for pulmonary adenocarcinoma development in humans, since Ki-ras oncogenes are detected in 35% of this human tumor type.

Links

J:68954 – MGI References
1352876 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C3H/HeJ x A/J)F1 Lung adenocarcinoma
  • vinyl carbamate (VC)
Lung

observed

(A/J x C3H/HeJ)F1 Lung adenoma
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Lung

observed

A/J Lung tumor Lung

90

A/J Lung tumor
  • vinyl carbamate (VC)
Lung

very high

C3H/HeJ Lung tumor Lung

5.0 - 10.0

C3H/HeJ Lung tumor
  • vinyl carbamate (VC)
Lung

observed

(C3H/HeJ x A/J)F1 Lung tumor Lung

sporadic - 50

(C3H/HeJ x A/J)F1 Lung tumor
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Lung

90

(C3H/HeJ x A/J)F1 Lung tumor
  • vinyl carbamate (VC)
Lung

90

(A/J x C3H/HeJ)F1 Lung tumor
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Lung

90

(A/J x C3H/HeJ)F1 Lung tumor
  • vinyl carbamate (VC)
Lung

90