Reference SummaryMeuwissen R, Oncogene 2001 Oct 4;20(45):6551-8
Title |
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. |
Authors |
Meuwissen R; Linn SC; van der Valk M; Mooi WJ; Berns A |
Journal |
Oncogene |
Volume |
20 |
Issue |
45 |
Year |
2001 |
Pages |
6551-8 |
Abstract |
The onset of human lung cancer occurs through sequential mutations in oncogenes and tumor suppressor genes. Mutations in K-Ras play a prominent role in human non-small cell lung cancer. We have developed a mouse lung tumor model in which K-Ras can be sporadically activated through Cre-lox mediated somatic recombination. Adenoviral mediated delivery of Cre recombinase in lung epithelial cells gave rise to rapid onset of tumorigenesis, yielding pulmonary adenocarcinomas with 100% incidence after a short latency. The lung tumor lesions shared many features with human non-small cell lung cancer. Our data show that sporadic expression of the K-Ras oncogene is sufficient to elicit lung tumorigenesis. Therefore this model has many advantages over conventional transgenic models used thus far. |
Links |
J:72206 – MGI References 11641780 – National Library of Medicine/PubMed |
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
FVB-Tg(GFP/KRAS2/ALPP)1Brn | Lung adenocarcinoma |
|
Lung |
100 |
|
FVB-Tg(GFP/KRAS2/ALPP)1Brn | Lung adenoma |
|
Lung |
100 |
|
FVB-Tg(GFP/KRAS2/ALPP)1Brn | Lung carcinoma |
|
Lung |
100 |
|
FVB-Tg(GFP/KRAS2/ALPP)1Brn | Lung neoplasia |
|
Lung |
80 |
|
FVB-Tg(GFP/KRAS2/ALPP)1Brn | Lung tumor |
|
Lung |
0 |
|
FVB/N | Lung tumor |
|
Lung |
0 |