Reference SummaryMalkinson AM, J Natl Cancer Inst 1985 Nov;75(5):971-4

Title

 Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model.

Authors

 Malkinson AM; Nesbitt MN; Skamene E

Journal

 J Natl Cancer Inst

Volume

 75

Issue

 5

Year

 1985

Pages

 971-4

Abstract

 For insight into the number of genes governing differential susceptibility such as in mice of the inbred strain A/J (A) highly susceptible to the induction of pulmonary adenomas by urethan in comparison to resistant strain C57BL/6J (B6) mice, tumor induction was studied in the AXB and BXA series of recombinant inbred (RI) strains derived respectively from A female X B6 male and B6 female X A male ancestral lines. Mice from 46 of these lines were given injections with 1 mg urethan/g (body wt), and the tumor number was assessed 4 months later. Lung tumor multiplicity for several RI lines was independently characterized in the Boulder, CO, and Montreal laboratories, and very similar numbers were obtained. Most lines had multiplicities intermediate to those of the progenitor strains, clearly indicating that more than a single gene accounted for the differences in lung tumor susceptibility between A and B6. The tumor incidence and multiplicity data fit very closely to what would be expected under a three-locus model, and we designated these genes Pas for pulmonary adenoma susceptibility. One locus called Pas-1 had an effect on tumor multiplicity greater than that of the other loci.

Links

 J:8075 – MGI References
3863994 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AXB1 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB2 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

36
AXB3 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB4 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

73
AXB5 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB6 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

86
AXB7 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB8 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB9 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB10 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

17
AXB11 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB12 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB13 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

43
AXB14 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

83
AXB15 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB17 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB18 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

80
AXB19 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

83
AXB20 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB21 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB22 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB23 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB24 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
AXB25 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA1 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

44
BXA2 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA3 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA4 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA6 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

50
BXA7 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA8 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA9 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA10 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

80
BXA11 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA12 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

67
BXA13 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA14 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

83
BXA16 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA17 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA18 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA19 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA20 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA22 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA23 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA24 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
BXA25 Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
A/J Lung adenoma
  • urethane (ethyl carbamate)
 Lung

100
C57BL/6J Lung adenoma
  • urethane (ethyl carbamate)
 Lung

48
BALB/cByJ Lung tumor
  • urethane (ethyl carbamate)
 Lung

observed