Reference SummaryLacroix-Triki M, Toxicol Pathol 2003 May-Jun;31(3):304-9

Title

Histiocytic Sarcoma in C57BL/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases.

Authors

Lacroix-Triki M; Lacoste-Collin L; Jozan S; Charlet JP; Caratero C; Courtade M

Journal

Toxicol Pathol

Volume

31

Issue

3

Year

2003

Pages

304-9

Abstract

Forty-one cases of histiocytic sarcoma (HS) in C57BL/6J mice were histopathologically studied with special regard to unexpected associated hematopoietic disorders. These cases were retrieved among C57BL/6J female mice used as control mice in a chronic low-dose irradiation experiment. Hematopoietic characteristics were analysed by comparison to 41 disease-free mice from the same cohort. Tumoral involvement of the liver was observed in all 41 HS-bearing mice, followed by infiltration of the spleen (61.8%), lung (32.4%), bone marrow (14.3%), uterus (12.2%), lymph node (9.8%), and kidney (2.4%). By comparative analysis, we were able to demonstrate a significant association of HS with liver hematopoiesis (89.5% in HS group vs 15% in control mice, p < 0.00001), and with central hematopoietic disorders involving the myelocytic cells (decreased in HS, p = 0.003) and erythrocytic cells (increased in HS, p = 0.001). Microscopic characteristics of these 41 cases and physiopathology of the newly described hematopoietic features in HS are further discussed.

Links

12746118 – National Library of Medicine/PubMed

Strain Notes

Strain Note
C57BL/6JIco Purchased from Charles River l'Arbresle, France (Iffa Credo).

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6JIco Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Liver

13

C57BL/6JIco Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Spleen

6.5

C57BL/6JIco Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus

1.5

C57BL/6JIco Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

13