Reference SummaryVerschoyle RD, Toxicol Pathol 2004 Jan-Feb;32(1):22-5

Title

Articular Chondromatosis and Chrondroid Metaplasia in Transgenic TAg Mice.

Authors

Verschoyle RD; Edwards R; Nolan B; Greaves P

Journal

Toxicol Pathol

Volume

32

Issue

1

Year

2004

Pages

22-5

Abstract

The C3(1)/SV40 T antigen transgenic mouse model for which rapid mammary and prostate tumor development has been documented uses the FVB/N mouse as a background strain. In this study, where the background strain used was the C57BL/6J mouse, neither mammary nor prostate tumors developed over periods of up to 40 weeks. However, a disturbance of hyaline cartilage in joints was observed similar to that found in synovial chondromatosis in humans. In addition, cartilage thickening in the external ears and cartilaginous metaplasia of the ascending aorta also occurred. This suggests that rearrangement of the transgene occurred in breeding on the C57BL background, thus modifying its expression. It raises the possibility that the genetic changes induced by the SV40 T antigen transforming sequence are important in cartilage homeostasis.

Links

J:88112 – MGI References
14713544 – National Library of Medicine/PubMed

Strain Notes

Strain Note
B6.FVB-Tg(C3-1-TAg)cJeg/J These mice were purchased from The Jackson Laboratory.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J Blood vessel - Aorta metaplasia - cartilaginous Blood vessel - Aorta

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Blood vessel - Aorta metaplasia - cartilaginous Blood vessel - Aorta

25

C57BL/6J Connective tissue - Cartilage - Articular hyperplasia Limb - Hindlimb

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Connective tissue - Cartilage - Articular hyperplasia Limb - Hindlimb

very high

C57BL/6J Connective tissue - Cartilage hyperplasia Bone - Sternum

0

C57BL/6J Connective tissue - Cartilage hyperplasia Ear - Outer ear

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Connective tissue - Cartilage hyperplasia Bone - Sternum

very high

B6.FVB-Tg(C3-1-TAg)cJeg/J Connective tissue - Cartilage hyperplasia Ear - Outer ear

very high

B6.FVB-Tg(C3-1-TAg)cJeg/J Connective tissue - Synovium hyperplasia Connective tissue - Synovium

very low

B6.FVB-Tg(C3-1-TAg)cJeg/J Connective tissue metaplasia Limb - Hindlimb

observed

B6.FVB-Tg(C3-1-TAg)cJeg/J Epididymis hyperplasia Epididymis

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Epididymis tumor Epididymis

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Heart - Heart valve metaplasia - cartilaginous Heart - Heart valve

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Intestine lesion Intestine

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Kidney lesion Kidney

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Liver lesion Liver

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Mammary gland hyperplasia Mammary gland

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Mammary gland tumor Mammary gland

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Muscle - Striated - Cardiac lesion Muscle - Striated - Cardiac

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Pancreas lesion Pancreas

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Prostate gland hyperplasia Prostate gland

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Prostate gland tumor Prostate gland

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Salivary gland lesion Salivary gland

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Seminal vesicle hyperplasia Seminal vesicle

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Seminal vesicle tumor Seminal vesicle

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Spleen lesion Spleen

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Testis hyperplasia Testis

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Testis tumor Testis

0

B6.FVB-Tg(C3-1-TAg)cJeg/J Thymus lesion Thymus

0