Strain SummaryC57BL/6

Strain Name

C57BL/6

Strain Type(s)

inbred

Strain Synonym(s)

B6  •  B6 wild-type  •  C57  •  C57/B16  •  C57B1/6  •  C57BL  •  C57Bl6  •  C57BL6  •  C57BL/6 wild-type  •  C57BL/6 WT  •  p53+/+  •  pure C57BL/6  •  wild-type  •  wild type C57BL/6  •  WT

Description

Substrain not specified.

Strain Links

• Festing's List of Inbred Strains

Models

97 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Cortex

87

0

References: Kim JS, Exp Anim 1997 Oct;46(4):303-6

Blood vessel hemangiosarcoma Blood vessel

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

CNS - Brain - Astrocyte astrocytoma CNS - Brain - Astrocyte

0

References: Reilly KM, Nat Genet 2000 Sep;26(1):109-13   ⋅   Weissenberger J, Oncogene 1997 May 1;14(17):2005-13

CNS - Brain glioma CNS - Brain Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb   ⋅   Moloney Murine Leukemia helper virus

observed

References: Johansson FK, Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11334-7

CNS - Brain tumor CNS - Brain MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)   ⋅   murine retrovirus containing human PDGFB cDNA

43

References: Uhrbom L, Cancer Res 1998 Dec 1;58(23):5275-9

CNS - Brain tumor CNS - Brain MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)

0

References: Uhrbom L, Cancer Res 1998 Dec 1;58(23):5275-9

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

0

References: Zoch A, PLoS One 2015;10(8):e0129151

Esophagus tumor Esophagus

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Esophagus tumor Esophagus rebamipide

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Esophagus tumor Esophagus N-ethyl-N'-nitro-N-nitroguanidine (ENNG)

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Esophagus tumor Esophagus N-ethyl-N'-nitro-N-nitroguanidine (ENNG)   ⋅   rebamipide

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Gallbladder normal tissue (control) Gallbladder

not applicable

References: Sundberg J, Personal Communication 1997;():

5 pathology image(s)

Intestine - Large Intestine - Colon hyperplasia Intestine - Large Intestine - Colon piroxicam

observed

References: Ritland SR, Carcinogenesis 1999 Jan;20(1):51-8

Intestine - Large Intestine - Colon tumor - malignant Intestine - Large Intestine - Colon cesium-137

4.0

References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981

Intestine - Small Intestine - Duodenum adenocarcinoma Intestine - Small Intestine - Duodenum N-ethyl-N'-nitro-N-nitroguanidine (ENNG)

67

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Intestine - Small Intestine - Duodenum adenocarcinoma Intestine - Small Intestine - Duodenum N-ethyl-N'-nitro-N-nitroguanidine (ENNG)   ⋅   rebamipide

42 - 55

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Intestine - Small Intestine - Duodenum tumor Intestine - Small Intestine - Duodenum

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Intestine - Small Intestine - Duodenum tumor Intestine - Small Intestine - Duodenum rebamipide

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Intestine adenoma Intestine

0

References: Sansom OJ, Cancer Res 2001 Oct 1;61(19):7060-4

Intestine adenoma Intestine aspirin (acetylsalicylic acid) (ASA)

0

References: Sansom OJ, Cancer Res 2001 Oct 1;61(19):7060-4

Kidney adenocarcinoma Kidney

0

References: Zoch A, PLoS One 2015;10(8):e0129151

Kidney cyst Kidney

5.56

References: Zoch A, PLoS One 2015;10(8):e0129151

Leukocyte - Lymphocyte leukemia Lymphoid tissue

observed

References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

2

References: Festing MFW, Mouse Genome 1996;94(3):523-677

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

10

22

References: Mahler JF, Toxicol Pathol 1996 Nov-Dec;24(6):710-6

Leukocyte leukemia Leukocyte

7.0 - 16.0

7

References: Festing MFW, Mouse Genome 1996;94(3):523-677   ⋅   Staats J, Cancer Res 1985 Mar;45(3):945-77

Leukocyte lymphoma Leukocyte A-MuLV - Abelson murine leukemia virus (A-MuLV-P160)

4.9 - 80

References: Risser R, Curr Top Microbiol Immunol 1985;122():162-8

Leukocyte lymphoma Leukocyte MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV)

0 - 33

References: Risser R, Curr Top Microbiol Immunol 1985;122():162-8

Leukocyte lymphoma Leukocyte methylcholanthrene (MCA)

high

References: Festing MFW, Mouse Genome 1996;94(3):523-677

Leukocyte lymphoma Leukocyte vinyl carbamate (VC)

100

References: Devereux TR, Mol Carcinog 1993;8(3):177-85

Leukocyte lymphoma Leukocyte

5.56

References: Zoch A, PLoS One 2015;10(8):e0129151

Leukocyte lymphoma Thymus cesium-137

24

20

References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981

Liver adenoma Liver dimethyl sulfoxide (DMSO)

0

References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5

Liver adenoma Liver dimethylnitrosamine (DMN)

33.33 - 76.47

References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5

Liver adenoma Liver 6-nitrochrysene (6-NC)

83.33 - 88.89

References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5

Liver adenoma Liver 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

5.56 - 7.14

References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5

Liver hepatocellular carcinoma Liver

0

References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30

Liver hepatocellular carcinoma Liver radiation - unspecified type

11.11

References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30

Liver hepatoma Liver radiation - unspecified type

high

References: Staats J, Cancer Res 1985 Mar;45(3):945-77

Liver hepatoma Liver

11.11

References: Zoch A, PLoS One 2015;10(8):e0129151

Liver preneoplastic lesion Liver diethylnitrosamine (DEN)

observed

References: Finnberg N, Cancer Lett 2004 Apr 30;207(2):149-55

Lung adenocarcinoma Lung 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

observed

References: Devereux TR, Mol Carcinog 1993;8(3):177-85

Lung adenocarcinoma Lung vinyl carbamate (VC)

observed

References: Devereux TR, Mol Carcinog 1993;8(3):177-85

Lung adenocarcinoma Lung

0

References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70

Lung adenocarcinoma Lung benzo[a]pyrene (BP) (BaP) (B[a]P)

42

References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70

Lung adenoma Lung vinyl carbamate (VC)

observed

References: Devereux TR, Mol Carcinog 1993;8(3):177-85

Lung adenoma Lung

0

5.56

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20   ⋅   Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70   ⋅   Zoch A, PLoS One 2015;10(8):e0129151

Lung adenoma Lung benzo[a]pyrene (BP) (BaP) (B[a]P)

0

References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70

Lung adenoma Lung mainstream cigarette smoke (MCS)

10

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung carcinoma Lung mainstream cigarette smoke (MCS)

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung carcinoma Lung

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung hyperplasia Lung benzo[a]pyrene (BP) (BaP) (B[a]P)

observed

References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70

Lung hyperplasia Lung

observed

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung hyperplasia Lung mainstream cigarette smoke (MCS)

observed

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung papilloma Lung

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung papilloma Lung mainstream cigarette smoke (MCS)

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung squamous cell carcinoma Lung

0

References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70

Lung squamous cell carcinoma Lung benzo[a]pyrene (BP) (BaP) (B[a]P)

23

References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70

Lung tumor Lung

0 - 4.4

1

References: D'Agostini F, Int J Oncol 2001 Mar;18(3):607-15   ⋅   Devereux TR, Mol Carcinog 1993;8(3):177-85   ⋅   Festing MFW, Mouse Genome 1996;94(3):523-677   ⋅   Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung tumor Lung N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)

observed

References: Festing MFW, Mouse Genome 1996;94(3):523-677

Lung tumor Lung N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Festing MFW, Mouse Genome 1996;94(3):523-677

Lung tumor Lung environmental cigarette smoke (ECS)

0

References: D'Agostini F, Int J Oncol 2001 Mar;18(3):607-15

Lung tumor Lung environmental cigarette smoke (ECS)   ⋅   N-acetyl-L-cysteine (NAC)

0

References: D'Agostini F, Int J Oncol 2001 Mar;18(3):607-15

Lung tumor Lung 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

18

References: Devereux TR, Mol Carcinog 1993;8(3):177-85

Lung tumor Lung vinyl carbamate (VC)

46

References: Devereux TR, Mol Carcinog 1993;8(3):177-85

Lung tumor Lung Adenovirus - recombinant, expressing Jaagsiekte sheep retrovirus envelope protein   ⋅   Adenovirus - recombinant, expressing human alkaline phosphatase

0 - 50

References: Wootton SK, Nature 2005 Apr 14;434(7035):904-7

Lung tumor Lung mainstream cigarette smoke (MCS)

observed - 10

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lymphoid tissue lymphoma Lymphoid tissue

0

References: Batten M, J Immunol 2004 Jan 15;172(2):812-22

Mammary gland adenocarcinoma Mammary gland

1

References: Festing MFW, Mouse Genome 1996;94(3):523-677

Mammary gland normal tissue (control) Mammary gland

not applicable

References: Pfefferle AD, Genome Biol 2013;14(11):R125

Mammary gland tumor Mammary gland

very low - low

References: Staats J, Companion to Mouse News Lett No. 21 1959;():

Mammary gland tumor Mammary gland cesium-137

4.0 - 8.0

References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast 3-methylcholanthrene (MCA) (3-MC)

observed

References: Festing MFW, Mouse Genome 1996;94(3):523-677

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

observed

References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30

Ovary tumor Ovary Ad5-CMV-Cre (AdCre) (AdCMVCre)

0

References: Wu R, Cancer Cell 2007 Apr;11(4):321-33

Ovary tumor - malignant Ovary cesium-137

4.0

References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981

Pancreas normal tissue (control) Pancreas

not applicable

References: Sundberg J, Personal Communication 1997;():

4 pathology image(s)

Pituitary gland tumor Pituitary gland

observed - 61

References: Murphy ED, 1966;():521-62   ⋅   Staats J, Cancer Res 1985 Mar;45(3):945-77

Prostate gland normal tissue (control) Prostate gland

not applicable

References: Deeb KK, Cancer Res 2007 Sep 1;67(17):8065-8080

Prostate gland tumor Prostate gland castration

0

References: Bruckheimer EM, Oncogene 2000 Nov 2;19(46):5251-8

Seminal vesicle normal tissue (control) Seminal vesicle

not applicable

References: Deeb KK, Cancer Res 2007 Sep 1;67(17):8065-8080

Skin carcinoma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

0

References: Woodworth CD, Carcinogenesis 2004 Sep;25(9):1771-8

Skin papilloma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

observed

References: Woodworth CD, Carcinogenesis 2004 Sep;25(9):1771-8

Spleen normal tissue (control) Spleen

not applicable

References: Sundberg J, Personal Communication 1997;():

12 pathology image(s)

Stomach tumor Stomach

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Stomach tumor Stomach rebamipide

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Stomach tumor Stomach N-ethyl-N'-nitro-N-nitroguanidine (ENNG)

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Stomach tumor Stomach N-ethyl-N'-nitro-N-nitroguanidine (ENNG)   ⋅   rebamipide

0

References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S

Thymus normal tissue (control) Thymus

not applicable

References: Sundberg J, Personal Communication 1997;():

8 pathology image(s)

Thymus thymoma Thymus A-MuLV - Abelson murine leukemia virus (A-MuLV-P160)

high

References: Risser R, Curr Top Microbiol Immunol 1985;122():162-8

Urinary bladder dysplasia Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

50

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder hyperplasia Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

observed

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder squamous cell carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

0

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

Urinary bladder transitional cell carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

20

References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11

(Unspecified organ) tumor (Unspecified organ)

0 - observed

low

References: Saitoh A, Oncogene 1990 Aug;5(8):1195-200   ⋅   Staats J, Cancer Res 1985 Mar;45(3):945-77   ⋅   Zoch A, PLoS One 2015;10(8):e0129151

(Unspecified organ) tumor (Unspecified organ) cesium-137

28

References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981

(Unspecified organ) tumor - unclassified (Unspecified organ) cesium-137

4.0

References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981