Strain SummaryC.129S2(B6)-Trp53tm1Tyj/J

Strain Name

 C.129S2(B6)-Trp53tm1Tyj/J

Strain Type(s)

 congenic  •  targeted mutation (knockout)

Strain Synonym(s)

 BALB/cJ-Trp53tm1Tyj  •  BALB-p53?/?  •  C.129S2(B6)-Trp53tm1Tyj  •  C.129S2-Trp53tm1Tyj/J  •  p53&delta  •  p53-/-

Description

 Homozygous mice. These mice have been fully backcrossed onto BALB/cJ. The original mutation was generated using 129S2/SvPas ES cells and was crossed to C57BL/6 before being backcrossed to BALB/cJ.

Strain Links

 • JAX Mice

Strain Genetics

 Trp53tm1Tyj / Trp53tm1Tyj

Models

11 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Cortex carcinoma Adrenal gland - Cortex

observed

References: Mikaelian I, Personal Communication 2002;():

Sites of Metastasis: Kidney , Liver

5 pathology image(s)
Blood vessel hemangiosarcoma Blood vessel

26

25

25

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

Bone osteosarcoma Bone

9.7

0

4.8

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

Leukocyte - Lymphocyte lymphoma Lymph node

observed

References: Mikaelian I, Personal Communication 2003;():

Sites of Metastasis: Lung

3 pathology image(s)
Leukocyte lymphoma Leukocyte

74

84

79 - 80

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

Leukocyte lymphoma Thymus

observed

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

Mammary gland carcinoma Mammary gland

6.5

0

3.2

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

observed

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

(Unspecified organ) carcinoma (Unspecified organ)

observed

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

(Unspecified organ) sarcoma (Unspecified organ)

9.7

3.1

6.3

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38

(Unspecified organ) tumor (Unspecified organ)

9.7

6.25

100

References: Landuzzi L, Oncotarget 2014 Dec 15;5(23):11924-38