Strain SummaryB6.129S2-Trp53tm1Tyj/J

Strain Name

 B6.129S2-Trp53tm1Tyj/J

Strain Type(s)

 congenic  •  targeted mutation (knockout)

Strain Synonym(s)

 B6.129S2-Trp53tm1Tyj  •  B6.129S2-Trp53tm1Tyj  •  C57BL/6J-Trp53tm1Tyj  •  p53-/-  •  p53 null (-/-)  •  p53-/-  •  p53-/-  •  p53 KO  •  p53-/-

Description

 Homozygous mice. The genetic background of these mice is congenic C57BL/6J.

Strain Links

 • JAX Mice

Strain Genetics

 Trp53tm1Tyj / Trp53tm1Tyj

Models

41 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
CNS - Brain glioma CNS - Brain retrovirus expressing human PDGFB

100

References: Deng Q, Nat Commun 2019 Nov 7;10(1):5061

Esophagus - Glandular metaplasia Esophagus - Glandular N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

19

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus - Glandular metaplasia Esophagus - Glandular N-nitrosomethylbenzylamine (NMBA)

0

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus hyperplasia Esophagus zinc-deficient

very high

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus hyperplasia Esophagus N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

observed

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus hyperplasia Esophagus

moderate

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus squamous cell carcinoma Esophagus N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

9.5

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus tumor Esophagus N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

38

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Esophagus tumor Esophagus N-nitrosomethylbenzylamine (NMBA)

0

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach hyperplasia Forestomach - Squamocolumnar junction with the glandular stomach zinc-deficient

very high

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach hyperplasia Forestomach - Squamocolumnar junction with the glandular stomach

moderate

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach papilloma Forestomach - Squamocolumnar junction with the glandular stomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

observed

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach tumor Forestomach - Squamocolumnar junction with the glandular stomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

100

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach - Squamocolumnar junction with the glandular stomach tumor Forestomach - Squamocolumnar junction with the glandular stomach N-nitrosomethylbenzylamine (NMBA)

74

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach hyperplasia Forestomach zinc-deficient

very high

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach hyperplasia Forestomach

moderate

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach papilloma Forestomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

observed

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach squamous cell carcinoma Forestomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

38

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach squamous cell carcinoma Forestomach N-nitrosomethylbenzylamine (NMBA)

5.3

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach tumor Forestomach N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

100

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Forestomach tumor Forestomach N-nitrosomethylbenzylamine (NMBA)

42

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte - Lymphocyte leukemia Liver

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Liver

observed

0

References: Mikaelian I, Personal Communication 2003;():   ⋅   Mukherjee M, PLoS One 2011;6(7):e22167

1 pathology image(s)
Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

observed - 70

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Thymus

observed

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Spleen

observed

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Lung

observed

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Kidney

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Intestine - Large Intestine - Colon

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte - Lymphocyte lymphoma Bone marrow

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

Leukocyte lymphoma Leukocyte zinc-deficient

40 - 70

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte lymphoma Thymus

40

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte lymphoma Thymus N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

4.3

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte lymphoma Leukocyte N-nitrosomethylbenzylamine (NMBA)   ⋅   zinc-deficient

35

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Leukocyte lymphoma Leukocyte N-nitrosomethylbenzylamine (NMBA)

16

References: Fong LY, Cancer Res 2003 Jan 1;63(1):186-95

Liver hepatocellular carcinoma Liver aflatoxin B1 (AFB1) (AFB1)

0

References: McGlynn KA, Cancer Res 2003 Aug 1;63(15):4594-601

Lymphoid tissue lymphoma Liver aflatoxin B1 (AFB1) (AFB1)

100

References: McGlynn KA, Cancer Res 2003 Aug 1;63(15):4594-601

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

50

References: Mukherjee M, PLoS One 2011;6(7):e22167

Testis - Germ cell teratoma Eye

observed

References: Smith RS, Comp Med 2002 Feb;52(1):68-72

(Unspecified organ) carcinoma (Unspecified organ)

0

References: Mukherjee M, PLoS One 2011;6(7):e22167

(Unspecified organ) tumor (Unspecified organ)

100

References: Mukherjee M, PLoS One 2011;6(7):e22167