Strain SummaryC57BL/6JIco
Strain Name |
C57BL/6JIco |
Strain Type(s) |
inbred |
Strain Synonym(s) |
C57BL/6 • C57Bl/6J • C57BL/6J • C57BL/6J Ico • Wild type • Wild-type • wild-type C57BL/6 • Wild-type C57BL/6J • WT |
Strain Links |
• Festing's List of Inbred Strains |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Adipose tissue lipoma | Abdominal cavity |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adipose tissue lipoma | CNS - Brain |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adipose tissue lipoma | CNS - Brain | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
0 |
0.8 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla | diethylstilbestrol (DES) |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
100 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell | diethylstilbestrol (DES) |
100 |
87 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Blood vessel hemangiosarcoma | Blood vessel |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Bone lesion | Bone - Sternum |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Bone lesion | Bone - Femur |
13 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Bone lesion | Bone - Sternum | diethylstilbestrol (DES) |
27 |
13 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Bone lesion | Bone - Femur | diethylstilbestrol (DES) |
100 |
87 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Bone lesion - fibro-osseous | Bone |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Bone lesion - fibro-osseous | Bone | estradiol (E2) |
93.3 |
66.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Bone osteosarcoma | Bone |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Bone osteosarcoma | Bone | diethylstilbestrol (DES) |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Bone osteosarcoma | Bone | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| CNS - Brain - Cerebrum glioma | CNS - Brain - Cerebrum |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| CNS - Brain - Cerebrum glioma | CNS - Brain - Cerebrum | diethylstilbestrol (DES) |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| CNS - Brain glioma | CNS - Brain |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| CNS - Brain glioma | CNS - Brain | diethylstilbestrol (DES) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Connective tissue - Fibroblast fibrosarcoma | Uterus - Cervix |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Connective tissue - Fibroblast fibrosarcoma | Uterus - Cervix | diethylstilbestrol (DES) |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Connective tissue - Fibroblast fibrosarcoma | Skin |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Forestomach tumor | Forestomach | benzo[a]pyrene (BP) (BaP) (B[a]P) |
6.7 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Gallbladder papilloma | Gallbladder | 2-acetamidofluorene (2-AAF) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Intestine - Small Intestine adenocarcinoma | Intestine - Small Intestine |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Intestine - Small Intestine adenocarcinoma | Intestine - Small Intestine | WY-14,643 |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
observed - 1.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Intestine tumor | Intestine | benzo[a]pyrene (BP) (BaP) (B[a]P) |
0 |
40 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Kidney hyperplasia | Kidney | phenacetin |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Kidney transitional cell carcinoma | Kidney | p-cresidine |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Kidney tumor | Kidney | phenacetin |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte - Lymphocyte - T-lymphocyte lymphoma | Leukocyte - Lymphocyte - T-lymphocyte |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Leukocyte - Lymphocyte - T-lymphocyte lymphoma | Leukocyte - Lymphocyte - T-lymphocyte | diethylstilbestrol (DES) |
0 |
6.7 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
13 |
References: Lacroix-Triki M, Toxicol Pathol 2003 May-Jun;31(3):304-9 18 pathology image(s) |
|||||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Spleen |
6.5 |
References: Lacroix-Triki M, Toxicol Pathol 2003 May-Jun;31(3):304-9 3 pathology image(s) |
|||||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Uterus |
1.5 |
References: Lacroix-Triki M, Toxicol Pathol 2003 May-Jun;31(3):304-9 |
|||||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0.8 - 13 |
0 |
References: Lacroix-Triki M, Toxicol Pathol 2003 May-Jun;31(3):304-9 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 Sites of Metastasis: Bone marrow , Kidney , Lung , Lymph node 11 pathology image(s) |
||||
| Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) | estradiol (E2) |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid | Leukocyte - Myelocyte (Granulocyte) |
0.8 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte lymphoma | Leukocyte |
0 - 2.5 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Leukocyte lymphoma | Leukocyte | benzo[a]pyrene (BP) (BaP) (B[a]P) |
13.3 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte lymphoma | Leukocyte | Cyclosporin A |
0 - 21.4 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte lymphoma | Leukocyte | diethylstilbestrol (DES) |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte lymphoma | Leukocyte | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Leukocyte lymphoma | Leukocyte | WY-14,643 |
0 |
6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver adenoma | Liver |
0 |
0 - observed |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Liver hepatocellular adenoma | Liver |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Liver hepatocellular adenoma | Liver | WY-14,643 |
6.7 |
13.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver hepatocellular carcinoma | Liver |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Liver hepatocellular carcinoma | Liver | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver hepatocellular carcinoma | Liver | WY-14,643 |
6.7 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver hyperplasia - oval cell | Liver |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Liver hyperplasia - oval cell | Liver | WY-14,643 |
46.7 |
40 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver tumor | Liver | p-cresidine |
10 |
0 - 33.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Liver tumor | Liver | 2-acetamidofluorene (2-AAF) |
10 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Lung adenoma | Lung |
0 |
2.5 - 6.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Lung adenoma | Lung | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mammary gland adenocarcinoma | Mammary gland |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mammary gland adenocarcinoma | Mammary gland | diethylstilbestrol (DES) |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mammary gland hyperplasia - focal | Mammary gland |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Mammary gland hyperplasia - focal | Mammary gland | diethylstilbestrol (DES) |
67 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Mesodermal cell/mesoblast sarcoma | CNS - Brain |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mesodermal cell/mesoblast sarcoma | Abdominal cavity |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mesodermal cell/mesoblast sarcoma | Skin |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Mesodermal cell/mesoblast sarcoma | Skin | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mesodermal cell/mesoblast sarcoma | CNS - Brain | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Mesodermal cell/mesoblast sarcoma | Abdominal cavity | estradiol (E2) |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Muscle - Smooth leiomyosarcoma | Muscle - Smooth |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Ovary - Germ cell teratoma | CNS - Brain |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Ovary - Germ cell teratoma | CNS - Brain | estradiol (E2) |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Ovary adenoma - tubulostromal | Ovary |
0.8 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis | diethylstilbestrol (DES) |
80 |
87 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Pituitary gland - Pars intermedia hyperplasia | Pituitary gland - Pars intermedia |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Pituitary gland - Pars intermedia hyperplasia | Pituitary gland - Pars intermedia | diethylstilbestrol (DES) |
47 |
67 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||
| Pituitary gland adenoma | Pituitary gland |
0 |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Pituitary gland adenoma | Pituitary gland | diethylstilbestrol (DES) |
13 - 13.3 |
13 - 13.3 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Placenta - Decidua deciduoma | Placenta - Decidua |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Prostate gland - Anterior lobe metaplasia - squamous | Prostate gland - Anterior lobe |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Prostate gland - Anterior lobe metaplasia - squamous | Prostate gland - Anterior lobe | diethylstilbestrol (DES) |
87 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Testis - Germ cell teratoma | CNS - Brain |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Testis - Germ cell teratoma | CNS - Brain | estradiol (E2) |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||||
| Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) | diethylstilbestrol (DES) |
6.7 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 ⋅ van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) |
0 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
|||||
| Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) | diethylstilbestrol (DES) |
53 |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| Thymus thymoma | Thymus |
0 |
0 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
0 |
0.8 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| Urinary bladder tumor | Urinary bladder | p-cresidine |
0 |
0 - 13.3 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Urinary bladder tumor | Urinary bladder | 2-acetamidofluorene (2-AAF) |
0 |
20 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| Uterus - Uterine gland hyperplasia | Uterus - Uterine gland | diethylstilbestrol (DES) |
observed |
References: McAnulty PA, Toxicol Pathol 2005;33(5):609-20 |
||||
| (Unspecified organ) tumor | (Unspecified organ) |
0 - 5.9 |
0 - 5.9 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
||||
| (Unspecified organ) tumor | (Unspecified organ) | benzo[a]pyrene (BP) (BaP) (B[a]P) |
20 |
46.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| (Unspecified organ) tumor | (Unspecified organ) | p-cresidine |
10 |
0 - 46.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| (Unspecified organ) tumor | (Unspecified organ) | 2-acetamidofluorene (2-AAF) |
10 |
20 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||
| (Unspecified organ) tumor | (Unspecified organ) | diethylstilbestrol (DES) |
13.3 |
26.7 |
References: van Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27 |
|||