Strain SummarySTOCK Erbb2tm8(Erbb2)Mul/+ Tg(MMTV-cre)7Mul

Strain Name

 STOCK Erbb2tm8(Erbb2)Mul/+ Tg(MMTV-cre)7Mul

Strain Type(s)

 targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

 Erbb2WT/NT  •  MMTV-Cre Flneo NeuNT  •  STOCK Erbb2tm(Erbb2)8Mul/+ Tg(MMTV-Cre)7Mul  •  TM

Description

 The genetic background of these mice was a mixture of 129X1/SvJ, 129S1/Sv, BALB/c, and FVB/N. The strain was heterozygous for the Erbb2tm(Erbb2)8Mul allele and carried the Tg(MMTV-cre)7Mul transgene.

Strain Genetics

 Tg(MMTV-cre)7Mul
Erbb2tm8(Erbb2)Mul / Erbb2+

Models

4 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Mammary gland adenocarcinoma - comedo Mammary gland

45

References: Andrechek ER, Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3444-9

1 pathology image(s)
Mammary gland hyperplasia - lobular-alveolar Mammary gland

observed - 92

References: Andrechek ER, Proc Natl Acad Sci U S A 2004 Apr 6;101(14):4984-9

2 pathology image(s)
Mammary gland lesion Mammary gland

100

References: Andrechek ER, Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3444-9

2 pathology image(s)
Mammary gland tumor Mammary gland

observed

References: Hodgson JG, Cancer Res 2005 Nov 1;65(21):9695-704